A random sequential adsorption model for protein adsorption to surfaces functionalized with poly(ethylene oxide)

Parag Katira, Ashutosh Agarwal, Henry Hess

Research output: Contribution to journalArticle

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Abstract

A random sequential adsorption (RSA) model, which focuses on the random distribution of polymer chains on the surface leading to polymer-free spots, was studied. RSA models of protein adsorption to bare surfaces was extended by modeling the grafted polymers as randomly distributed, preexisting obstacles on the surface. The space occupied by the polymer chain was modeled as spherical with a radius equal to the radius of gyration of the polymer chain. It was observed that protein adsorption decreases rapidly with an increasing number of ethylene oxide units in the PEO chains, because the size of the open space required for adsorption rapidly increases with the increasing height of the polymer chain. The application of the RSA model may be limited in systems which permit the reorganization of PEO chains into ordered arrangements after the initial adsorption, because the model assumes a random placement.

Original languageEnglish (US)
Pages (from-to)1599-1604
Number of pages6
JournalAdvanced Materials
Volume21
Issue number16
DOIs
StatePublished - Apr 27 2009
Externally publishedYes

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ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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