A radical demise. Toxins and trauma share common pathways in hair cell death

Richard Kopke, Keith A. Allen, Donald Henderson, Michael E Hoffer, Dorothy Frenz, Thomas R Van De Water

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

The pathologic similarities noted after ototoxic and/or traumatic injury to the cochlea as well as the key features of the cochlea that make it susceptible to reactive oxygen species (ROS) damage are reviewed. Recent evidence linking ROS to cochlear damage associated with both ototoxins and/or trauma are presented. Mechanisms of generation of ROS in the cochlea and how these metabolites damage the cochlea and impair function are also reviewed. Finally, examples of novel therapeutic strategies to prevent and reverse hearing loss due to noise and/or ototoxins are presented to illustrate the clinical relevance of these new findings.

Original languageEnglish
Pages (from-to)171-191
Number of pages21
JournalAnnals of the New York Academy of Sciences
Volume884
StatePublished - Jan 1 1999
Externally publishedYes

Fingerprint

Cochlea
Cell death
Reactive Oxygen Species
Cell Death
Wounds and Injuries
Audition
Metabolites
Acoustic noise
Hearing Loss
Noise
Cells
Trauma
Pathway
Demise
Oxygen
Damage

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kopke, R., Allen, K. A., Henderson, D., Hoffer, M. E., Frenz, D., & Van De Water, T. R. (1999). A radical demise. Toxins and trauma share common pathways in hair cell death. Annals of the New York Academy of Sciences, 884, 171-191.

A radical demise. Toxins and trauma share common pathways in hair cell death. / Kopke, Richard; Allen, Keith A.; Henderson, Donald; Hoffer, Michael E; Frenz, Dorothy; Van De Water, Thomas R.

In: Annals of the New York Academy of Sciences, Vol. 884, 01.01.1999, p. 171-191.

Research output: Contribution to journalArticle

Kopke, R, Allen, KA, Henderson, D, Hoffer, ME, Frenz, D & Van De Water, TR 1999, 'A radical demise. Toxins and trauma share common pathways in hair cell death', Annals of the New York Academy of Sciences, vol. 884, pp. 171-191.
Kopke, Richard ; Allen, Keith A. ; Henderson, Donald ; Hoffer, Michael E ; Frenz, Dorothy ; Van De Water, Thomas R. / A radical demise. Toxins and trauma share common pathways in hair cell death. In: Annals of the New York Academy of Sciences. 1999 ; Vol. 884. pp. 171-191.
@article{11d98ffa32cd4953b4577c07ce17b316,
title = "A radical demise. Toxins and trauma share common pathways in hair cell death",
abstract = "The pathologic similarities noted after ototoxic and/or traumatic injury to the cochlea as well as the key features of the cochlea that make it susceptible to reactive oxygen species (ROS) damage are reviewed. Recent evidence linking ROS to cochlear damage associated with both ototoxins and/or trauma are presented. Mechanisms of generation of ROS in the cochlea and how these metabolites damage the cochlea and impair function are also reviewed. Finally, examples of novel therapeutic strategies to prevent and reverse hearing loss due to noise and/or ototoxins are presented to illustrate the clinical relevance of these new findings.",
author = "Richard Kopke and Allen, {Keith A.} and Donald Henderson and Hoffer, {Michael E} and Dorothy Frenz and {Van De Water}, {Thomas R}",
year = "1999",
month = "1",
day = "1",
language = "English",
volume = "884",
pages = "171--191",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - A radical demise. Toxins and trauma share common pathways in hair cell death

AU - Kopke, Richard

AU - Allen, Keith A.

AU - Henderson, Donald

AU - Hoffer, Michael E

AU - Frenz, Dorothy

AU - Van De Water, Thomas R

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The pathologic similarities noted after ototoxic and/or traumatic injury to the cochlea as well as the key features of the cochlea that make it susceptible to reactive oxygen species (ROS) damage are reviewed. Recent evidence linking ROS to cochlear damage associated with both ototoxins and/or trauma are presented. Mechanisms of generation of ROS in the cochlea and how these metabolites damage the cochlea and impair function are also reviewed. Finally, examples of novel therapeutic strategies to prevent and reverse hearing loss due to noise and/or ototoxins are presented to illustrate the clinical relevance of these new findings.

AB - The pathologic similarities noted after ototoxic and/or traumatic injury to the cochlea as well as the key features of the cochlea that make it susceptible to reactive oxygen species (ROS) damage are reviewed. Recent evidence linking ROS to cochlear damage associated with both ototoxins and/or trauma are presented. Mechanisms of generation of ROS in the cochlea and how these metabolites damage the cochlea and impair function are also reviewed. Finally, examples of novel therapeutic strategies to prevent and reverse hearing loss due to noise and/or ototoxins are presented to illustrate the clinical relevance of these new findings.

UR - http://www.scopus.com/inward/record.url?scp=0032787487&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032787487&partnerID=8YFLogxK

M3 - Article

VL - 884

SP - 171

EP - 191

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -