Asymptomatic bacteriuria (ASB) in young nonpregnant women is considered a benign condition, but little is known about its pathogenesis, risk factors and association with symptomatic urinary tract infection (UTI). We evaluated women for ASB as part of a larger prospective study of UTI among 348 university women (U) and 448 women in a health maintenance organization (H), age 18-40, who were followed for 6 months. Subjects were asked to submit urine cultures monthly and to keep a daily diary in which information about exposures of interest were recorded. ASB was defined as ≥105 cfu of a uropathogen/ml of midstream urine in the absence of UTI symptoms. Overall, there were 146 person-years of follow-up in the U cohort and 177 person-years in the H cohort. We observed 132 episodes of ASB among 75 women (range per woman, 0 to 7) in the U cohort for a point prevalence of 4.6% (95% CI: 3.5%. 6.1%) and 139 episodes among 89 women (range per woman, 0 to 6) in the H cohort for a similar point prevalence of 5.5% (95% CI: 4.3%, 7.0%). Risk factors for ASB were the same as those for UTI although the associations were weaker: diaphragm-spermicide use (OR 1.6 al U, P<.0001; and 1.5 at H, P=.0001); recent sexual intercourse (OR 1.3 at U, P=.0002); cervical cap use (OR 1.4 at U; P=.002); a history of recurrent UTI (OR 2.2 at H; P=.01); and any use of spermicide alone (OR 2.5 at H; P=.007). Among women with ASB at U and H. 8% had a UTI within a week vs. 1% of those without ASB (U: OR=8.0[4.1, 15.5]; p<.0001 and H: OR=15.5 [6.6, 36.0]; p<.0001). We conclude that ASB is relatively common in young sexually active women, is associated with factors also predisposing to symptomatic UTI and is associated with subsequent occurrence of symptomatic UTI.
|Original language||English (US)|
|Number of pages||1|
|Journal||Clinical Infectious Diseases|
|State||Published - Dec 1 1997|
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases