Abstract
A mathematical model for prediction of response to endocrine therapy of breast cancer has been developed based on a clonal concept of metastatic spread. The model includes an expression of the likelihood of response of an estrogen receptor-positive site and an expression of the concordance of receptor assays when multiple sites are assayed. Both of these are raised to a power function based on the number of sites of metastases to yield a predicted response rate. An excellent fit of the predictions of this mathematical model and response data from a series of patients receiving endocrine therapy was observed. This model provides a worthwhile insight into the biology of response to endocrine therapy. The model may be extended and refined through additional analyses.
Original language | English (US) |
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Pages (from-to) | 2423-2427 |
Number of pages | 5 |
Journal | Cancer Research |
Volume | 40 |
Issue number | 7 |
State | Published - Jul 1 1980 |
ASJC Scopus subject areas
- Oncology
- Cancer Research