A proposal for new clinical concepts in the management of atrial fibrillation

A. John Camm, Sana M. Al-Khatib, Hugh Calkins, Jonathan L. Halperin, Paulus Kirchhof, Gregory Y H Lip, Stanley Nattel, Jeremy Ruskin, Amitava Banerjee, Dan Blendea, Eduard Guasch, Matthew Needleman, Irina Savelieva, Juan Viles Gonzalez, Eric S. Williams

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Atrial fibrillation (AF) represents a growing public health burden. It is a complex condition, involving a number of etiologic factors and arrhythmia mechanisms associated with atrial remodeling. Greater understanding of these mechanisms may improve therapy. Current AF classification schemes are limited by simplicity. A number of risk factors predict AF onset, and additional factors are being evaluated in registry studies. Doppler imaging and Holter monitoring in high-risk patients to predict the onset of AF and progression from paroxysmal to permanent AF are promising. There is a need for a novel multifactorial classification model encompassing AF duration, symptoms, markers of atrial remodeling, and a risk score for AF onset, persistence, progression, and complications to guide treatment and prognostication. Preventing AF onset with upstream therapy is of great interest, but current data are conflicting. More study is needed to optimize rhythm control with antiarrhythmic drugs and targeted ablation to specific patient populations at an earlier stage. There is little consensus on optimal rate control and no information relating to optimum rate control in specific populations. This article highlights new concepts in AF and directions for future research.

Original languageEnglish
JournalAmerican Heart Journal
Volume164
Issue number3
DOIs
StatePublished - Sep 1 2012
Externally publishedYes

Fingerprint

Atrial Fibrillation
Atrial Remodeling
Ambulatory Electrocardiography
Anti-Arrhythmia Agents
Population
Registries
Cardiac Arrhythmias
Therapeutics
Public Health

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Camm, A. J., Al-Khatib, S. M., Calkins, H., Halperin, J. L., Kirchhof, P., Lip, G. Y. H., ... Williams, E. S. (2012). A proposal for new clinical concepts in the management of atrial fibrillation. American Heart Journal, 164(3). https://doi.org/10.1016/j.ahj.2012.05.017

A proposal for new clinical concepts in the management of atrial fibrillation. / Camm, A. John; Al-Khatib, Sana M.; Calkins, Hugh; Halperin, Jonathan L.; Kirchhof, Paulus; Lip, Gregory Y H; Nattel, Stanley; Ruskin, Jeremy; Banerjee, Amitava; Blendea, Dan; Guasch, Eduard; Needleman, Matthew; Savelieva, Irina; Viles Gonzalez, Juan; Williams, Eric S.

In: American Heart Journal, Vol. 164, No. 3, 01.09.2012.

Research output: Contribution to journalArticle

Camm, AJ, Al-Khatib, SM, Calkins, H, Halperin, JL, Kirchhof, P, Lip, GYH, Nattel, S, Ruskin, J, Banerjee, A, Blendea, D, Guasch, E, Needleman, M, Savelieva, I, Viles Gonzalez, J & Williams, ES 2012, 'A proposal for new clinical concepts in the management of atrial fibrillation', American Heart Journal, vol. 164, no. 3. https://doi.org/10.1016/j.ahj.2012.05.017
Camm AJ, Al-Khatib SM, Calkins H, Halperin JL, Kirchhof P, Lip GYH et al. A proposal for new clinical concepts in the management of atrial fibrillation. American Heart Journal. 2012 Sep 1;164(3). https://doi.org/10.1016/j.ahj.2012.05.017
Camm, A. John ; Al-Khatib, Sana M. ; Calkins, Hugh ; Halperin, Jonathan L. ; Kirchhof, Paulus ; Lip, Gregory Y H ; Nattel, Stanley ; Ruskin, Jeremy ; Banerjee, Amitava ; Blendea, Dan ; Guasch, Eduard ; Needleman, Matthew ; Savelieva, Irina ; Viles Gonzalez, Juan ; Williams, Eric S. / A proposal for new clinical concepts in the management of atrial fibrillation. In: American Heart Journal. 2012 ; Vol. 164, No. 3.
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