Abstract
Extensive polymorphism at the major histocompatibility complex (MHC) is thought to confer immune protection on populations. A New World primate, the cotton-top tamarin (Saguinus oedipus), has a high prevalence of ulcerative colitis and adenocarcinoma of the colon and dies after infection with several human viruses. Lymphocytes from all animals tested expressed one common MHC class I allelic product. Another MHC class I allelic product was expressed by 39 of 41 tested animals. Four other allelic products were also expressed on the lymphocytes of these animals at a frequency of >50%. MHC class II gene products, however, were polymorphic. Restriction fragment length polymorphism analysis confirmed that there were a limited number of cotton-top tamarin MHC class I alleles, whereas the MHC class II gene loci were polymorphic. This sharing of MHC class I alleles is unprecedented in a higher primate species and may play a role in the susceptibility of this endangered species to pathogens.
| Original language | English |
|---|---|
| Pages (from-to) | 7714-7718 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 85 |
| Issue number | 20 |
| State | Published - Jan 1 1988 |
| Externally published | Yes |
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ASJC Scopus subject areas
- General
- Genetics
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A primate species with limited major histocompatibility complex class I polymorphism. / Watkins, David; Hodi, F. S.; Letvin, N. L.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, No. 20, 01.01.1988, p. 7714-7718.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A primate species with limited major histocompatibility complex class I polymorphism
AU - Watkins, David
AU - Hodi, F. S.
AU - Letvin, N. L.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - Extensive polymorphism at the major histocompatibility complex (MHC) is thought to confer immune protection on populations. A New World primate, the cotton-top tamarin (Saguinus oedipus), has a high prevalence of ulcerative colitis and adenocarcinoma of the colon and dies after infection with several human viruses. Lymphocytes from all animals tested expressed one common MHC class I allelic product. Another MHC class I allelic product was expressed by 39 of 41 tested animals. Four other allelic products were also expressed on the lymphocytes of these animals at a frequency of >50%. MHC class II gene products, however, were polymorphic. Restriction fragment length polymorphism analysis confirmed that there were a limited number of cotton-top tamarin MHC class I alleles, whereas the MHC class II gene loci were polymorphic. This sharing of MHC class I alleles is unprecedented in a higher primate species and may play a role in the susceptibility of this endangered species to pathogens.
AB - Extensive polymorphism at the major histocompatibility complex (MHC) is thought to confer immune protection on populations. A New World primate, the cotton-top tamarin (Saguinus oedipus), has a high prevalence of ulcerative colitis and adenocarcinoma of the colon and dies after infection with several human viruses. Lymphocytes from all animals tested expressed one common MHC class I allelic product. Another MHC class I allelic product was expressed by 39 of 41 tested animals. Four other allelic products were also expressed on the lymphocytes of these animals at a frequency of >50%. MHC class II gene products, however, were polymorphic. Restriction fragment length polymorphism analysis confirmed that there were a limited number of cotton-top tamarin MHC class I alleles, whereas the MHC class II gene loci were polymorphic. This sharing of MHC class I alleles is unprecedented in a higher primate species and may play a role in the susceptibility of this endangered species to pathogens.
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M3 - Article
C2 - 2902637
AN - SCOPUS:0023686189
VL - 85
SP - 7714
EP - 7718
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 20
ER -