A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border: The Nuevo Día study

Jane M. Simoni, John S. Wiebe, John A. Sauceda, David Huh, Giselle Sanchez, Virginia Longoria, C. Andres Bedoya, Steven Safren

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of "moderate" to "large" size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = -3.64, p = 0.05) and greater adherence according to the electronic pillbox (OR = 3.78, p = 0.03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted.

Original languageEnglish (US)
Pages (from-to)2816-2829
Number of pages14
JournalAIDS and Behavior
Volume17
Issue number8
DOIs
StatePublished - 2013
Externally publishedYes

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Mexico
Hispanic Americans
Self Report
Biomarkers
HIV
Depression
Cognitive Therapy
CD4 Lymphocyte Count
Maintenance

Keywords

  • ART adherence
  • CBT
  • Depression
  • HIV/AIDS
  • Latino/Hispanic

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Social Psychology

Cite this

A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border : The Nuevo Día study. / Simoni, Jane M.; Wiebe, John S.; Sauceda, John A.; Huh, David; Sanchez, Giselle; Longoria, Virginia; Andres Bedoya, C.; Safren, Steven.

In: AIDS and Behavior, Vol. 17, No. 8, 2013, p. 2816-2829.

Research output: Contribution to journalArticle

Simoni, Jane M. ; Wiebe, John S. ; Sauceda, John A. ; Huh, David ; Sanchez, Giselle ; Longoria, Virginia ; Andres Bedoya, C. ; Safren, Steven. / A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border : The Nuevo Día study. In: AIDS and Behavior. 2013 ; Vol. 17, No. 8. pp. 2816-2829.
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