A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border: The Nuevo Día study

Jane M. Simoni; John S. Wiebe; John A. Sauceda; David Huh; Giselle Sanchez; Virginia Longoria; C. Andres Bedoya; Steven A. Safren

doi:10.1007/s10461-013-0538-5

A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border: The Nuevo Día study

Jane M. Simoni, John S. Wiebe, John A. Sauceda, David Huh, Giselle Sanchez, Virginia Longoria, C. Andres Bedoya, Steven A. Safren

Psychology

Research output: Contribution to journal › Article

49 Scopus citations

Abstract

We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of "moderate" to "large" size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = -3.64, p = 0.05) and greater adherence according to the electronic pillbox (OR = 3.78, p = 0.03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted.

Original language	English (US)
Pages (from-to)	2816-2829
Number of pages	14
Journal	AIDS and Behavior
Volume	17
Issue number	8
DOIs	https://doi.org/10.1007/s10461-013-0538-5
State	Published - 2013

Keywords

ART adherence
CBT
Depression
HIV/AIDS
Latino/Hispanic

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

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Simoni, J. M., Wiebe, J. S., Sauceda, J. A., Huh, D., Sanchez, G., Longoria, V., Andres Bedoya, C., & Safren, S. A. (2013). A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border: The Nuevo Día study. AIDS and Behavior, 17(8), 2816-2829. https://doi.org/10.1007/s10461-013-0538-5

A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border : The Nuevo Día study. / Simoni, Jane M.; Wiebe, John S.; Sauceda, John A.; Huh, David; Sanchez, Giselle; Longoria, Virginia; Andres Bedoya, C.; Safren, Steven A.

In: AIDS and Behavior, Vol. 17, No. 8, 2013, p. 2816-2829.

Research output: Contribution to journal › Article

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