A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border: The Nuevo Día study

Jane M. Simoni; John S. Wiebe; John A. Sauceda; David Huh; Giselle Sanchez; Virginia Longoria; C. Andres Bedoya; Steven A. Safren

doi:10.1007/s10461-013-0538-5

A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border: The Nuevo Día study

Jane M. Simoni, John S. Wiebe, John A. Sauceda, David Huh, Giselle Sanchez, Virginia Longoria, C. Andres Bedoya, Steven A. Safren

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of "moderate" to "large" size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = -3.64, p = 0.05) and greater adherence according to the electronic pillbox (OR = 3.78, p = 0.03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted.

Original language	English (US)
Pages (from-to)	2816-2829
Number of pages	14
Journal	AIDS and Behavior
Volume	17
Issue number	8
DOIs	https://doi.org/10.1007/s10461-013-0538-5
State	Published - Oct 2013
Externally published	Yes

Keywords

ART adherence
CBT
Depression
HIV/AIDS
Latino/Hispanic

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

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A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border : The Nuevo Día study. / Simoni, Jane M.; Wiebe, John S.; Sauceda, John A.; Huh, David; Sanchez, Giselle; Longoria, Virginia; Andres Bedoya, C.; Safren, Steven A.

In: AIDS and Behavior, Vol. 17, No. 8, 10.2013, p. 2816-2829.

Research output: Contribution to journal › Article › peer-review

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abstract = "We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of {"}moderate{"} to {"}large{"} size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = -3.64, p = 0.05) and greater adherence according to the electronic pillbox (OR = 3.78, p = 0.03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted.",

keywords = "ART adherence, CBT, Depression, HIV/AIDS, Latino/Hispanic",

author = "Simoni, {Jane M.} and Wiebe, {John S.} and Sauceda, {John A.} and David Huh and Giselle Sanchez and Virginia Longoria and {Andres Bedoya}, C. and Safren, {Steven A.}",

note = "Funding Information: Acknowledgments We are grateful to the patients and staff of Centro de Salud Familiar la Fe CARE Center, Inc. for their participation and facilitation of this study. We thank members of our community and administrative advisory boards as well as research consultants Jaime Anaya, Kurt C. Organista, Steffanie A. Strathdee, Karina Walters, and Randolph Whitworth. We would also like to thank those who aided with project implementation, including Jessica Armendariz, Teresa Frias, Carolina Lara, Chrisie Lemon, Virginia Longoria, Elsa Martin, Antonio Martinez, Miriam Pando, Tatiana Rodriguez, and Cesar Villareal Ramos from the University of Texas at El Paso, and Kimberly Nelson, Cynthia Pearson, and Samantha Yard from the University of Washington. This research project was supported by the National Institute of Mental Health (Grant # 1R34MH08674 and minority research supplement award # R34MH084674-S1) and in part by the Center for AIDS Research (Grant # P30 AI027757).",

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N2 - We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of "moderate" to "large" size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = -3.64, p = 0.05) and greater adherence according to the electronic pillbox (OR = 3.78, p = 0.03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted.

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A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border: The Nuevo Día study

Abstract

Keywords

ASJC Scopus subject areas

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