Abstract
We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of "moderate" to "large" size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = -3.64, p = 0.05) and greater adherence according to the electronic pillbox (OR = 3.78, p = 0.03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2816-2829 |
| Number of pages | 14 |
| Journal | AIDS and Behavior |
| Volume | 17 |
| Issue number | 8 |
| DOIs | |
| State | Published - 2013 |
| Externally published | Yes |
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Keywords
- ART adherence
- CBT
- Depression
- HIV/AIDS
- Latino/Hispanic
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Infectious Diseases
- Social Psychology
Cite this
A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border : The Nuevo Día study. / Simoni, Jane M.; Wiebe, John S.; Sauceda, John A.; Huh, David; Sanchez, Giselle; Longoria, Virginia; Andres Bedoya, C.; Safren, Steven.
In: AIDS and Behavior, Vol. 17, No. 8, 2013, p. 2816-2829.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A preliminary RCT of CBT-AD for adherence and depression among HIV-positive latinos on the U.S.-Mexico border
T2 - The Nuevo Día study
AU - Simoni, Jane M.
AU - Wiebe, John S.
AU - Sauceda, John A.
AU - Huh, David
AU - Sanchez, Giselle
AU - Longoria, Virginia
AU - Andres Bedoya, C.
AU - Safren, Steven
PY - 2013
Y1 - 2013
N2 - We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of "moderate" to "large" size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = -3.64, p = 0.05) and greater adherence according to the electronic pillbox (OR = 3.78, p = 0.03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted.
AB - We conducted a preliminary RCT among 40 HIV-positive Latinos of Mexican descent on the U.S.-Mexico border who indicated imperfect adherence and depressive symptomatology. Participants were randomly assigned to culturally adapted cognitive-behavioral therapy for adherence and depression with an alarmed pillbox or usual care. Outcomes were depressive symptoms (self-report and blind clinician ratings), adherence (self-report and electronic pillbox), and biological markers. The intervention, delivered in English and Spanish, proved feasible and acceptable. Generalized estimating equations in intent-to-treat analyses showed some effects of "moderate" to "large" size, with maintenance over time. For example, intervention (vs. control) participants demonstrated at post-intervention a greater drop in BDI scores (OR = -3.64, p = 0.05) and greater adherence according to the electronic pillbox (OR = 3.78, p = 0.03). Biological markers indicated some relative improvement for CD4 count but not VL. The promising results suggest a larger trial to determine efficacy is warranted.
KW - ART adherence
KW - CBT
KW - Depression
KW - HIV/AIDS
KW - Latino/Hispanic
UR - http://www.scopus.com/inward/record.url?scp=84885435321&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885435321&partnerID=8YFLogxK
U2 - 10.1007/s10461-013-0538-5
DO - 10.1007/s10461-013-0538-5
M3 - Article
C2 - 23812892
AN - SCOPUS:84885435321
VL - 17
SP - 2816
EP - 2829
JO - AIDS and Behavior
JF - AIDS and Behavior
SN - 1090-7165
IS - 8
ER -