A positron emission tomographic study of auditory localization in the congenitally blind

Robert Weeks, Barry Horwitz, Ali Aziz-Sultan, Biao Tian, C. Mark Wessinger, Leonardo G. Cohen, Mark Hallett, Josef P. Rauschecker

Research output: Contribution to journalArticle

349 Citations (Scopus)

Abstract

We have used positron emission tomography (PET) to measure regional cerebral blood flow (rCBF) in sighted and congenitally blind subjects performing auditory localization tasks. During scanning, the spectral and binaural cues of localized sound were reproduced by a sound system and delivered via headphones. During tasks that required auditory localization both the sighted and blind subjects strongly activated posterior parietal areas. In addition, the blind subjects activated association areas in the right occipital cortex, the foci of which were similar to areas previously identified in visual location and motion detection experiments in sighted subjects. The blind subjects, therefore, demonstrated visual to auditory crossmodal plasticity with auditory localization activating occipital association areas originally intended for dorsal-stream visual processing. To determine the functional connectivity of pre-selected brain regions in primary and non-primary auditory and posterior parietal cortex in the two cohorts, we performed an inter-regional correlation analysis on the rCBF data set. During auditory localization in the blind subjects, rCBF activity in the right posterior parietal cortex was positively correlated with that in the right occipital region, whereas in sighted subjects correlations were generally negative. There were no significant positive occipital correlations in either cohort when reference regions in temporal or left parietal cortex were chosen. This indicates that in congenitally blind subjects the right occipital cortex participates in a functional network for auditory localization and that occipital activity is more likely to arise from connections with posterior parietal cortex.

Original languageEnglish
Pages (from-to)2664-2672
Number of pages9
JournalJournal of Neuroscience
Volume20
Issue number7
StatePublished - Apr 1 2000

Fingerprint

Sound Localization
Cerebrovascular Circulation
Parietal Lobe
Occipital Lobe
Electrons
Regional Blood Flow
Temporal Lobe
Positron-Emission Tomography
Cues
Brain

Keywords

  • Blindness
  • Cross-modal plasticity
  • Extrastriate
  • Parietal cortex
  • Positron emission tomography
  • Sound localization

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Weeks, R., Horwitz, B., Aziz-Sultan, A., Tian, B., Wessinger, C. M., Cohen, L. G., ... Rauschecker, J. P. (2000). A positron emission tomographic study of auditory localization in the congenitally blind. Journal of Neuroscience, 20(7), 2664-2672.

A positron emission tomographic study of auditory localization in the congenitally blind. / Weeks, Robert; Horwitz, Barry; Aziz-Sultan, Ali; Tian, Biao; Wessinger, C. Mark; Cohen, Leonardo G.; Hallett, Mark; Rauschecker, Josef P.

In: Journal of Neuroscience, Vol. 20, No. 7, 01.04.2000, p. 2664-2672.

Research output: Contribution to journalArticle

Weeks, R, Horwitz, B, Aziz-Sultan, A, Tian, B, Wessinger, CM, Cohen, LG, Hallett, M & Rauschecker, JP 2000, 'A positron emission tomographic study of auditory localization in the congenitally blind', Journal of Neuroscience, vol. 20, no. 7, pp. 2664-2672.
Weeks R, Horwitz B, Aziz-Sultan A, Tian B, Wessinger CM, Cohen LG et al. A positron emission tomographic study of auditory localization in the congenitally blind. Journal of Neuroscience. 2000 Apr 1;20(7):2664-2672.
Weeks, Robert ; Horwitz, Barry ; Aziz-Sultan, Ali ; Tian, Biao ; Wessinger, C. Mark ; Cohen, Leonardo G. ; Hallett, Mark ; Rauschecker, Josef P. / A positron emission tomographic study of auditory localization in the congenitally blind. In: Journal of Neuroscience. 2000 ; Vol. 20, No. 7. pp. 2664-2672.
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