A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset

Corinne L. Lendon, Amanda Myers, Alistair Cumming, Alison M. Goate, David St. Clair

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Mutations in the presenilin 1 gene account for many cases of early onset familial Alzheimer's disease. Homozygosity for the 'T' allele of a polymorphism in the presenilin 1 gene has previously been reported to double the risk for-Alzheimer's disease in a late onset Caucasian sample. Here we report that this polymorphism does not incur risk in a case control sample of early onset Alzheimer's disease, possibly suggesting a different disease etiology between the early and late onset forms.

Original languageEnglish (US)
Pages (from-to)212-214
Number of pages3
JournalNeuroscience Letters
Volume228
Issue number3
DOIs
StatePublished - Jun 13 1997
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Association study
  • Early onset
  • Presenilin
  • Sporadic

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'A polymorphism in the presenilin 1 gene does not modify risk for Alzheimer's disease in a cohort with sporadic early onset'. Together they form a unique fingerprint.

  • Cite this