A placebo-controlled, double-blind comparison of clobazam and diazepam in the treatment of anxiety

A. F. Jacobson, B. J. Goldstein, R. A. Dominguez, R. M. Steinbook

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In a randomized, placebo-controlled, double-blind study, the efficacy and safety of clobazam and diazepam were compared in 114 anxious outpatients. During the 4-week double-blind phase of the study, the mean daily dose was 59 mg for clobazam and 25 mg for diazepam. Results indicate statistically significant efficacy, measured by both patient and physician rating scales, for both active drugs compared to placebo. The incidence of sedation was similar for the two active treatment groups; dizziness was more frequent in the diazepam group.

Original languageEnglish
Pages (from-to)296-300
Number of pages5
JournalJournal of Clinical Psychiatry
Volume44
Issue number8 I
StatePublished - Jan 1 1983
Externally publishedYes

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Diazepam
Anxiety
Placebos
Double-Blind Method
Dizziness
Outpatients
Therapeutics
Physicians
Safety
Incidence
Pharmaceutical Preparations
clobazam

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Jacobson, A. F., Goldstein, B. J., Dominguez, R. A., & Steinbook, R. M. (1983). A placebo-controlled, double-blind comparison of clobazam and diazepam in the treatment of anxiety. Journal of Clinical Psychiatry, 44(8 I), 296-300.

A placebo-controlled, double-blind comparison of clobazam and diazepam in the treatment of anxiety. / Jacobson, A. F.; Goldstein, B. J.; Dominguez, R. A.; Steinbook, R. M.

In: Journal of Clinical Psychiatry, Vol. 44, No. 8 I, 01.01.1983, p. 296-300.

Research output: Contribution to journalArticle

Jacobson, AF, Goldstein, BJ, Dominguez, RA & Steinbook, RM 1983, 'A placebo-controlled, double-blind comparison of clobazam and diazepam in the treatment of anxiety', Journal of Clinical Psychiatry, vol. 44, no. 8 I, pp. 296-300.
Jacobson AF, Goldstein BJ, Dominguez RA, Steinbook RM. A placebo-controlled, double-blind comparison of clobazam and diazepam in the treatment of anxiety. Journal of Clinical Psychiatry. 1983 Jan 1;44(8 I):296-300.
Jacobson, A. F. ; Goldstein, B. J. ; Dominguez, R. A. ; Steinbook, R. M. / A placebo-controlled, double-blind comparison of clobazam and diazepam in the treatment of anxiety. In: Journal of Clinical Psychiatry. 1983 ; Vol. 44, No. 8 I. pp. 296-300.
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