A pituitary carcinoma secreting TSH and prolactin: A non-secreting adenoma gone awry

Rebecca L. Brown, Tariq Muzzafar, Robert Wollman, Roy E Weiss

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

To our knowledge, only one case of a TSH-secreting carcinoma has previously been reported. We describe here a second patient with a pituitary carcinoma producing TSH and prolactin (PRL). A 37-year-old male underwent a left frontotemporal craniotomy in 1996 for a sellar mass. Except for mildly increased PRL and elevated α-subunit, hormone evaluation was normal. Pathologic examination revealed a chromophobe adenoma with increased mitotic forms. The patient completed a course of external beam radiation to the pituitary and was prescribed L-thyroxine, bromocriptine, and hydrocortisone. He was lost to follow-up but did well for 6 years, until 2002, when he presented with TSH-dependent thyrotoxicosis and hyperprolactinemia. The patient was started on bromocriptine and propylthiouracil and was, again, lost to follow-up. In 2004, 9 years after his initial presentation, he presented after falling. Magnetic resonance imaging showed two brain masses with associated midline shift. Emergent resection of the larger mass revealed a pituitary cancer with positive staining for PRL, but not for TSH. Nine months later, the patient underwent further debulking of metastatic disease. Although development of a carcinoma from a pituitary adenoma is very rare (<0.5%), macroadenomas that become hormonally active should be suspect for transformation into pituitary cancer.

Original languageEnglish (US)
Pages (from-to)639-643
Number of pages5
JournalEuropean Journal of Endocrinology
Volume154
Issue number5
DOIs
StatePublished - May 2006
Externally publishedYes

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Pituitary Neoplasms
Prolactin
Adenoma
Bromocriptine
Lost to Follow-Up
Chromophobe Adenoma
Accidental Falls
Carcinoma
Propylthiouracil
Hyperprolactinemia
Thyrotoxicosis
Craniotomy
Thyroxine
Hydrocortisone
Magnetic Resonance Imaging
Hormones
Radiation
Staining and Labeling
Brain

ASJC Scopus subject areas

  • Endocrinology

Cite this

A pituitary carcinoma secreting TSH and prolactin : A non-secreting adenoma gone awry. / Brown, Rebecca L.; Muzzafar, Tariq; Wollman, Robert; Weiss, Roy E.

In: European Journal of Endocrinology, Vol. 154, No. 5, 05.2006, p. 639-643.

Research output: Contribution to journalArticle

Brown, Rebecca L. ; Muzzafar, Tariq ; Wollman, Robert ; Weiss, Roy E. / A pituitary carcinoma secreting TSH and prolactin : A non-secreting adenoma gone awry. In: European Journal of Endocrinology. 2006 ; Vol. 154, No. 5. pp. 639-643.
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