A pilot study of the cognitive and psychological correlates of chronic ciguatera poisoning

P. Arena, Bonnie Levin, L. E. Fleming, M. A. Friedman, D. Blythe

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Ciguatera fish poisoning is the most frequently reported seafood-toxin illness in the world, caused by the consumption of coral reef fishes contaminated with a group of natural toxins produced by minute phytoplankton (dinoflagellates). These toxins are potent and cause both acute and chronic neurologic disease in humans. Although ciguatera fish poisoning is associated with established neurotoxins in animal models, and with known peripheral nervous system effects in humans, this pilot study was the first to explore possible central nervous system effects associated with chronic ciguatera poisoning in humans. In a matched cohort design, 12 cases and 12 their age and gender matched friend controls underwent a battery of neuropsychological tests. The results indicated that although their scores on objective neuropsychological tests did not differ significantly from matched controls, persons with ciguatera reported a higher degree of toxicity-related symptomatology and endorsed significantly more depressive symptomatology than controls. Future research should explore larger numbers of persons with both acute and chronic ciguatera, with and without mannitol treatment.

Original languageEnglish
Pages (from-to)51-60
Number of pages10
JournalHarmful Algae
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2004

Fingerprint

ciguatera
poisoning
toxin
nervous system
fish
seafood
toxins
dinoflagellate
coral reef
natural toxicants
gender
peripheral nervous system
phytoplankton
nervous system diseases
neurotoxins
toxicity
seafoods
mannitol
animal
coral reefs

Keywords

  • Ciguatera fish poisoning
  • Ciguatoxin
  • Harmful algal blooms
  • Mannitol
  • Marine toxins
  • Neuropsychologic effects

ASJC Scopus subject areas

  • Aquatic Science

Cite this

A pilot study of the cognitive and psychological correlates of chronic ciguatera poisoning. / Arena, P.; Levin, Bonnie; Fleming, L. E.; Friedman, M. A.; Blythe, D.

In: Harmful Algae, Vol. 3, No. 1, 01.01.2004, p. 51-60.

Research output: Contribution to journalArticle

Arena, P. ; Levin, Bonnie ; Fleming, L. E. ; Friedman, M. A. ; Blythe, D. / A pilot study of the cognitive and psychological correlates of chronic ciguatera poisoning. In: Harmful Algae. 2004 ; Vol. 3, No. 1. pp. 51-60.
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