A pilot study of cidofovir for progressive multifocal leukoencephalopathy in AIDS

Christina M. Marra, Natasa Rajicic, David E. Barker, Bruce A. Cohen, David Clifford, M. Judith Donovan Post, Armando Ruiz, Brian C. Bowen, Meei Li Huang, Jennie Queen-Baker, Janet Andersen, Sue Kelly, Sharon Shriver

Research output: Contribution to journalArticle

165 Scopus citations

Abstract

Objective: To assess the safety, tolerability and effect of cidofovir for HIV-1 associated progressive multifocal leukoencephalopathy. Design: Prospective, open-label study in nine AIDS Clinical Trials Units. Patients and methods: Twenty-four HIV-1-infected individuals, with neuroimaging and clinical findings consistent with PML, and symptoms for 90 days or less, whose diagnosis was confirmed by the detection of JC virus DNA in the cerebrospinal fluid or brain biopsy, received cidofovir 5 mg/kg intravenously at baseline and 1 week, followed by infusions every 2 weeks with the dose adjusted for renal function. Follow-up continued to 24 weeks. The safety of cidofovir and changes in neurological examination scores between baseline and week 8 were assessed. Results: Seventeen subjects were receiving potent antiretroviral agents. Survival at 12 weeks was 54%. The CD4 cell count at entry was significantly associated with survival (P = 0.02). Five subjects discontinued treatment because of toxicity: a 50% or greater decrease in intraocular pressure in either eye in four, and proteinuria in one. Overall, magnetic resonance imaging abnormalities and neurological examination scores worsened. Only two subjects experienced a 25% or greater improvement in neurological examination scores at week 8, which were significantly better in subjects with HIV-1-RNA levels of 500 copies/ml or less at entry compared with those with HIV-1-RNA levels over 500 copies/ml (P = 0.05). Conclusion: Cidofovir did not improve neurological examination scores at week 8. However, such scores were significantly better in subjects who entered with suppressed plasma HIV-1-RNA levels, which could be the result of control of HIV-1 infection itself or cidofovir.

Original languageEnglish (US)
Pages (from-to)1791-1797
Number of pages7
JournalAIDS
Volume16
Issue number13
DOIs
StatePublished - Sep 6 2002

Keywords

  • Cidofovir
  • HIV
  • JC virus
  • Magnetic resonance imaging
  • Neurological examination
  • Polymerase chain reaction
  • Progressive multifocal leukoencephalopathy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Marra, C. M., Rajicic, N., Barker, D. E., Cohen, B. A., Clifford, D., Donovan Post, M. J., Ruiz, A., Bowen, B. C., Huang, M. L., Queen-Baker, J., Andersen, J., Kelly, S., & Shriver, S. (2002). A pilot study of cidofovir for progressive multifocal leukoencephalopathy in AIDS. AIDS, 16(13), 1791-1797. https://doi.org/10.1097/00002030-200209060-00012