A pilot randomized controlled trial of brief cognitive-behavioral therapy for anxiety in patients with terminal cancer

Joseph A. Greer, Lara Traeger, Heather Bemis, Jessica Solis, Ellen S. Hendriksen, Elyse R. Park, William F. Pirl, Jennifer S. Temel, Holly G. Prigerson, Steven Safren

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Introduction. Patients with terminal cancer often experience marked anxiety that is associated with poor quality of life. Although cognitive-behavioral therapy (CBT) is an evidencebased treatment for anxiety disorders, the approach needs to be adapted to address realistic concerns related to having cancer, such as worries about disease progression, disability, and death. In this pilot randomized controlled trial (clinicaltrials. gov identifier NCT00706290), we examined the feasibility and potential efficacy of brief CBT to reduce anxiety in patients with terminal cancer. Methods. We adapted CBT by developing treatment modules targeting skills for relaxation, coping with cancer worries, and activity pacing. Adults with incurable malignancies and elevated anxiety based on the Hamilton Anxiety Rating Scale (HAM-A) were randomly assigned to individual CBT or a waitlist control group. Primary outcomes included the number of completed CBT visits and the change in HAM-A scores from baseline to 8-week follow- up per a treatment-blind evaluator. The feasibility criterion was 75% adherence to the intervention. Results. We randomized 40 patients with terminal cancers toCBT(n=20) or waitlist control (n=20) groups;70%completed posttreatment assessments. Most patients who received CBT (80%) participated in at least five of the required six therapy sessions. Analysis of covariance models, adjusted for baseline scores, showed that those assigned to CBT had greater improvements in HAM-A scores compared to the control group, with an adjusted mean difference of -5.41 (95% confidence interval: -10.78 to -0.04) and a large effect size for the intervention (Cohen's d = 0.80). Conclusion. Providing brief CBT tailored to the concerns of patients with terminal cancer was not only feasible but also led to significant improvements in anxiety.

Original languageEnglish (US)
Pages (from-to)1337-1345
Number of pages9
JournalOncologist
Volume17
Issue number10
DOIs
StatePublished - 2012
Externally publishedYes

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Cognitive Therapy
Anxiety
Randomized Controlled Trials
Neoplasms
Control Groups
Psychological Adaptation
Therapeutics
Anxiety Disorders
Disease Progression
Quality of Life
Confidence Intervals

Keywords

  • Anxiety
  • Cancer
  • Cognitive behavior therapy
  • Quality of life

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

A pilot randomized controlled trial of brief cognitive-behavioral therapy for anxiety in patients with terminal cancer. / Greer, Joseph A.; Traeger, Lara; Bemis, Heather; Solis, Jessica; Hendriksen, Ellen S.; Park, Elyse R.; Pirl, William F.; Temel, Jennifer S.; Prigerson, Holly G.; Safren, Steven.

In: Oncologist, Vol. 17, No. 10, 2012, p. 1337-1345.

Research output: Contribution to journalArticle

Greer, JA, Traeger, L, Bemis, H, Solis, J, Hendriksen, ES, Park, ER, Pirl, WF, Temel, JS, Prigerson, HG & Safren, S 2012, 'A pilot randomized controlled trial of brief cognitive-behavioral therapy for anxiety in patients with terminal cancer', Oncologist, vol. 17, no. 10, pp. 1337-1345. https://doi.org/10.1634/theoncologist.2012-0041
Greer, Joseph A. ; Traeger, Lara ; Bemis, Heather ; Solis, Jessica ; Hendriksen, Ellen S. ; Park, Elyse R. ; Pirl, William F. ; Temel, Jennifer S. ; Prigerson, Holly G. ; Safren, Steven. / A pilot randomized controlled trial of brief cognitive-behavioral therapy for anxiety in patients with terminal cancer. In: Oncologist. 2012 ; Vol. 17, No. 10. pp. 1337-1345.
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T1 - A pilot randomized controlled trial of brief cognitive-behavioral therapy for anxiety in patients with terminal cancer

AU - Greer, Joseph A.

AU - Traeger, Lara

AU - Bemis, Heather

AU - Solis, Jessica

AU - Hendriksen, Ellen S.

AU - Park, Elyse R.

AU - Pirl, William F.

AU - Temel, Jennifer S.

AU - Prigerson, Holly G.

AU - Safren, Steven

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N2 - Introduction. Patients with terminal cancer often experience marked anxiety that is associated with poor quality of life. Although cognitive-behavioral therapy (CBT) is an evidencebased treatment for anxiety disorders, the approach needs to be adapted to address realistic concerns related to having cancer, such as worries about disease progression, disability, and death. In this pilot randomized controlled trial (clinicaltrials. gov identifier NCT00706290), we examined the feasibility and potential efficacy of brief CBT to reduce anxiety in patients with terminal cancer. Methods. We adapted CBT by developing treatment modules targeting skills for relaxation, coping with cancer worries, and activity pacing. Adults with incurable malignancies and elevated anxiety based on the Hamilton Anxiety Rating Scale (HAM-A) were randomly assigned to individual CBT or a waitlist control group. Primary outcomes included the number of completed CBT visits and the change in HAM-A scores from baseline to 8-week follow- up per a treatment-blind evaluator. The feasibility criterion was 75% adherence to the intervention. Results. We randomized 40 patients with terminal cancers toCBT(n=20) or waitlist control (n=20) groups;70%completed posttreatment assessments. Most patients who received CBT (80%) participated in at least five of the required six therapy sessions. Analysis of covariance models, adjusted for baseline scores, showed that those assigned to CBT had greater improvements in HAM-A scores compared to the control group, with an adjusted mean difference of -5.41 (95% confidence interval: -10.78 to -0.04) and a large effect size for the intervention (Cohen's d = 0.80). Conclusion. Providing brief CBT tailored to the concerns of patients with terminal cancer was not only feasible but also led to significant improvements in anxiety.

AB - Introduction. Patients with terminal cancer often experience marked anxiety that is associated with poor quality of life. Although cognitive-behavioral therapy (CBT) is an evidencebased treatment for anxiety disorders, the approach needs to be adapted to address realistic concerns related to having cancer, such as worries about disease progression, disability, and death. In this pilot randomized controlled trial (clinicaltrials. gov identifier NCT00706290), we examined the feasibility and potential efficacy of brief CBT to reduce anxiety in patients with terminal cancer. Methods. We adapted CBT by developing treatment modules targeting skills for relaxation, coping with cancer worries, and activity pacing. Adults with incurable malignancies and elevated anxiety based on the Hamilton Anxiety Rating Scale (HAM-A) were randomly assigned to individual CBT or a waitlist control group. Primary outcomes included the number of completed CBT visits and the change in HAM-A scores from baseline to 8-week follow- up per a treatment-blind evaluator. The feasibility criterion was 75% adherence to the intervention. Results. We randomized 40 patients with terminal cancers toCBT(n=20) or waitlist control (n=20) groups;70%completed posttreatment assessments. Most patients who received CBT (80%) participated in at least five of the required six therapy sessions. Analysis of covariance models, adjusted for baseline scores, showed that those assigned to CBT had greater improvements in HAM-A scores compared to the control group, with an adjusted mean difference of -5.41 (95% confidence interval: -10.78 to -0.04) and a large effect size for the intervention (Cohen's d = 0.80). Conclusion. Providing brief CBT tailored to the concerns of patients with terminal cancer was not only feasible but also led to significant improvements in anxiety.

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