A pilot clinical and pharmacological study of intra-arterial infusion of Thiotepa

Niramol Savaraj, Lynn G Feun, G. Blyden, Jose Yrizarry, J. T G Hsiang, J. Curtas, S. Waldman, M. Judith Post, Pasquale W Benedetto, Howard Landy, J. J. Guerra

Research output: Contribution to journalArticle

Abstract

Fourteen patients with progressive localized tumors were treated on a clinical and pharmacological study with intra-arterial Thiotepa. A transfemoral percutaneous catheter was inserted into the major artery supplying the tumor. A venous catheter was inserted into the vein draining the tumor area for blood sampling. Doses of Thiotepa ranged from 0.3 mg/kg to 1.0 mg/kg. Courses were repeated monthly and doses of drug escalated as tolerated. Toxicity was mild and doses of drug at least up to 0.9-1.0 mg/kg were tolerable. Pharmacokinetic parameters suggest increasing binding of Thiotepa to tissue when the drug is administered by the intra-arterial route. Clinical responses were observed in a patient with melanoma and in another patient with unknown primary cancer.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalCancer Biotherapy
Volume8
Issue number1
StatePublished - Jan 1 1993

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Thiotepa
Intra Arterial Infusions
Pharmacology
Neoplasms
Catheters
Pharmaceutical Preparations
Veins
Melanoma
Pharmacokinetics
Arteries
Clinical Studies

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

Savaraj, N., Feun, L. G., Blyden, G., Yrizarry, J., Hsiang, J. T. G., Curtas, J., ... Guerra, J. J. (1993). A pilot clinical and pharmacological study of intra-arterial infusion of Thiotepa. Cancer Biotherapy, 8(1), 37-42.

A pilot clinical and pharmacological study of intra-arterial infusion of Thiotepa. / Savaraj, Niramol; Feun, Lynn G; Blyden, G.; Yrizarry, Jose; Hsiang, J. T G; Curtas, J.; Waldman, S.; Judith Post, M.; Benedetto, Pasquale W; Landy, Howard; Guerra, J. J.

In: Cancer Biotherapy, Vol. 8, No. 1, 01.01.1993, p. 37-42.

Research output: Contribution to journalArticle

Savaraj, N, Feun, LG, Blyden, G, Yrizarry, J, Hsiang, JTG, Curtas, J, Waldman, S, Judith Post, M, Benedetto, PW, Landy, H & Guerra, JJ 1993, 'A pilot clinical and pharmacological study of intra-arterial infusion of Thiotepa', Cancer Biotherapy, vol. 8, no. 1, pp. 37-42.
Savaraj N, Feun LG, Blyden G, Yrizarry J, Hsiang JTG, Curtas J et al. A pilot clinical and pharmacological study of intra-arterial infusion of Thiotepa. Cancer Biotherapy. 1993 Jan 1;8(1):37-42.
Savaraj, Niramol ; Feun, Lynn G ; Blyden, G. ; Yrizarry, Jose ; Hsiang, J. T G ; Curtas, J. ; Waldman, S. ; Judith Post, M. ; Benedetto, Pasquale W ; Landy, Howard ; Guerra, J. J. / A pilot clinical and pharmacological study of intra-arterial infusion of Thiotepa. In: Cancer Biotherapy. 1993 ; Vol. 8, No. 1. pp. 37-42.
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