A pilot clinical and pharmacological study of intra-arterial infusion of Thiotepa

N. Savaraj, L. G. Feun, G. Blyden, J. M. Yrizarry, J. T.G. Hsiang, J. Curtas, S. Waldman, J. D. Post, P. Benedetto, H. Landy, Jorge J. Guerra

Research output: Contribution to journalArticlepeer-review


Fourteen patients with progressive localized tumors were treated on a clinical and pharmacological study with intra-arterial Thiotepa. A transfemoral percutaneous catheter was inserted into the major artery supplying the tumor. A venous catheter was inserted into the vein draining the tumor area for blood sampling. Doses of Thiotepa ranged from 0.3 mg/kg to 1.0 mg/kg. Courses were repeated monthly and doses of drug escalated as tolerated. Toxicity was mild and doses of drug at least up to 0.9-1.0 mg/kg were tolerable. Pharmacokinetic parameters suggest increasing binding of Thiotepa to tissue when the drug is administered by the intra-arterial route. Clinical responses were observed in a patient with melanoma and in another patient with unknown primary cancer.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalCancer Biotherapy
Issue number1
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Pharmacology
  • Cancer Research


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