A physiological role for tRNA nucleotidyltransferase during bacteriophage infection

Jeffrey W. Morse, Murray P Deutscher

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Bacteriophage infection of E. coli cells deficient in the enzyme tRNA nucleotidyltransferase (cca mutants) resulted in greatly decreased production of viable progeny phage compared to wild type cells. This decrease amounted to as much as 90% in the case of T-even bacteriophages, and 50-65% for T-odd bacteriophages. However, infection by the RNA phages, Qβ and f2, was unaffected by the cca mutation. Examination of T4 infection of cca hosts of progeny particles were formed, but that most of these particles were nonviable. Possible functions for E. coli tRNA nucleotidyltransferase during bacteriophage infection are discussed.

Original languageEnglish
Pages (from-to)953-959
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume73
Issue number4
DOIs
StatePublished - Dec 20 1976
Externally publishedYes

Fingerprint

Bacteriophages
T-Phages
Infection
RNA Phages
Escherichia coli Infections
Escherichia coli
Mutation
Enzymes
tRNA nucleotidyltransferase
RNA

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

A physiological role for tRNA nucleotidyltransferase during bacteriophage infection. / Morse, Jeffrey W.; Deutscher, Murray P.

In: Biochemical and Biophysical Research Communications, Vol. 73, No. 4, 20.12.1976, p. 953-959.

Research output: Contribution to journalArticle

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