A photodimerization approach to crosslink and functionalize microgels

Sanjeev Sirpal, Kerim M. Gattás-Asfura, Roger Leblanc

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Microgels were prepared within reverse micelles via photocrosslinking. Gelation resulted from the [2 + 2] photodimerization reaction of nitrocinnamoyl (NC) groups on multi-arm polyethylene glycol (PEG) or gelatin. Because of the potential for biomedical and chemical applications, immobilization capacity within the microgels was investigated. Quantum dots (QDs), for example, share a similar size scale with proteins and can be physically trapped within the microgels. In addition, the optoelectronic properties of QDs could be utilized for analytical, imaging, and therapeutic purposes. Small molecules and recognition sequences (e.g. biotin) can also be covalently immobilized within the microgel networks through the photodimerization reaction. In the presence of biotin-PEG-NC, the resulting microgels added to streptavidin-coated plates. The microgel properties such as biodegradability and degree of swelling may be engineered for particular applications including targeted monitoring and controlled drug delivery systems.

Original languageEnglish
Pages (from-to)116-120
Number of pages5
JournalColloids and Surfaces B: Biointerfaces
Volume58
Issue number2
DOIs
StatePublished - Aug 1 2007

Fingerprint

Quantum Dots
biotin
Biotin
Polyethylene glycols
Semiconductor quantum dots
glycols
polyethylenes
quantum dots
Controlled drug delivery
biodegradability
Streptavidin
Biodegradability
gelatins
gelation
Micelles
Gelation
Gelatin
Drug Delivery Systems
immobilization
Immobilization

Keywords

  • Drug delivery
  • Immobilization
  • Microgel
  • Photocrosslinking
  • Reverse micelle

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

Cite this

A photodimerization approach to crosslink and functionalize microgels. / Sirpal, Sanjeev; Gattás-Asfura, Kerim M.; Leblanc, Roger.

In: Colloids and Surfaces B: Biointerfaces, Vol. 58, No. 2, 01.08.2007, p. 116-120.

Research output: Contribution to journalArticle

Sirpal, Sanjeev ; Gattás-Asfura, Kerim M. ; Leblanc, Roger. / A photodimerization approach to crosslink and functionalize microgels. In: Colloids and Surfaces B: Biointerfaces. 2007 ; Vol. 58, No. 2. pp. 116-120.
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