A phase II open-label trial of apomine (SR-45023A) in patients with refractory melanoma

Karl D. Lewis, John A. Thompson, Jeffrey S. Weber, William A. Robinson, Steven O'Day, Jose Lutzky, Sewa S. Legha, Simon Floret, Francis Ruvuna, Rene Gonzalez

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Metastatic melanoma continues to be a very difficult disease to treat. Options are limited and often have very little impact on the course of the disease. The objective of the current study was to evaluate the efficacy and safety of continuously administered Apomine (SR-45023A), a novel bisphosphonate, in patients with previously treated metastatic malignant melanoma. Adult patients with previously treated metastatic melanoma received Apomine 100 mg orally, twice daily (total dose 200 mg per day) continuously for 28 days (defined as a cycle). Treatment was continued until disease progression or unacceptable toxicity. A total of 42 patients received at least one dose of Apomine. Stable disease was achieved in 2 patients (5%). No complete or partial responses were observed. Progression free survival of at least 16 weeks was observed in 6 patients (14%). The median overall survival was 6.1 months (95% CI, 4.9-9.4 months). Time to treatment failure was 1.7 months (95% CI, 1.6-1.8 months) with Apomine therapy. By cycle 2, Apomine concentrations reached steady-state. Apomine was well tolerated with only 37% of patients experiencing any drug-related event. Abdominal pain was the most frequent adverse event occurring in 26% of patients. In conclusion, Apomine, at the current dose studied, failed to produce a 30% progression free survival rate at 16 weeks considered to be a meaningful benefit for further development.

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalInvestigational New Drugs
Volume24
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

Keywords

  • Apomine
  • Biphosphonate
  • HMG CoA reductase
  • Melanoma

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Pharmacology (medical)

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