A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours

B. A. Wilky, M. A. Rudek, S. Ahmed, D. A. Laheru, D. Cosgrove, R. C. Donehower, B. Nelkin, D. Ball, L. A. Doyle, H. Chen, X. Ye, G. Bigley, C. Womack, N. S. Azad

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Background: We completed a phase I clinical trial to test the safety and toxicity of combined treatment with cixutumumab (anti-IGF-1R antibody) and selumetinib (MEK 1/2 inhibitor). Methods: Patients with advanced solid tumours, refractory to standard therapy received selumetinib hydrogen sulphate capsules orally twice daily, and cixutumumab intravenously on days 1 and 15 of each 28-day cycle. The study used a 3+3 design, with a dose-finding cohort followed by an expansion cohort at the maximally tolerated dose that included pharmacokinetic and pharmacodynamic correlative studies. Results: Thirty patients were enrolled, with 16 in the dose-finding cohort and 14 in the expansion cohort. Grade 3 or greater toxicities included nausea and vomiting, anaemia, CVA, hypertension, hyperglycaemia, and ophthalmic symptoms. The maximally tolerated combination dose was 50 mg twice daily of selumetinib and 12 mg kg-1 every 2 weeks of cixutumumab. Two patients achieved a partial response (one unconfirmed), including a patient with BRAF wild-type thyroid carcinoma, and a patient with squamous cell carcinoma of the tongue, and six patients achieved time to progression of >6 months, including patients with thyroid carcinoma, colorectal carcinoma, and basal cell carcinoma. Comparison of pre- and on-treatment biopsies showed significant suppression of pERK and pS6 activity with treatment. Conclusions: Our study of anti-IGF-1R antibody cixutumumab and MEK 1/2 inhibitor selumetinib showed that the combination is safe and well-tolerated at these doses, with preliminary evidence of clinical benefit and pharmacodynamic evidence of target inhibition.

Original languageEnglish (US)
Pages (from-to)24-31
Number of pages8
JournalBritish Journal of Cancer
Volume112
Issue number1
DOIs
StatePublished - Jan 6 2015

Keywords

  • BRAF
  • IGF
  • IGF-1R
  • MEK
  • clinical trial

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Wilky, B. A., Rudek, M. A., Ahmed, S., Laheru, D. A., Cosgrove, D., Donehower, R. C., Nelkin, B., Ball, D., Doyle, L. A., Chen, H., Ye, X., Bigley, G., Womack, C., & Azad, N. S. (2015). A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours. British Journal of Cancer, 112(1), 24-31. https://doi.org/10.1038/bjc.2014.515