Abstract
Objectives: The thioxanthone analog, SR271425, is a novel cytotoxic DNA-interacting agent with broad antitumor activity in preclinical models. The objectives of this phase I study were to determine the dose-limiting toxicities, maximum tolerated dose, recommended phase II dose, pharmacokinetic profile, and trend for efficacy in patients with advanced cancer. Methods: SR271425 was administered intravenously over 1-hour, weekly for 2 weeks, followed by 1 week rest. Because of Cmax-related corrected QT (QTc) prolongation in preclinical testing of SR271425, all patients underwent an extensive pretreatment cardiac assessment. Results: Eighteen patients received SR271425 at 5 dose levels ranging from 64 to 675 mg/m2/wk. No dose-limiting toxicities were identified. In all tested dose-levels, Grade 3 adverse events were observed in 10/18 patients (55.6%) and Grade 4 in 4/18 patients (22.2%). QTc prolongation was reported at the 3 highest dose levels but did not exceed Grade 2. Six deaths occurred during the study, 5 of them because of disease progression and 1 because of disease related bowel perforation. SR271425 exposure increased in a near dose-proportional manner. The mean terminal plasma half-life of SR271425 was 6 hours and there was no drug accumulation after repeated dosing. Stable disease was the best outcome observed (5 patients). Conclusions: SR271425 was administered safely at doses up to 675 mg/ m2/wk on a 2-week on, 1-week off schedule. No dose-limiting toxicities were observed. Grade 2 QTc prolongation was observed at the highest dose levels. Maximum tolerated dose was not reached because of early termination of the SR271425 program by the sponsor.
Original language | English (US) |
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Pages (from-to) | 9-14 |
Number of pages | 6 |
Journal | American Journal of Clinical Oncology: Cancer Clinical Trials |
Volume | 32 |
Issue number | 1 |
DOIs | |
State | Published - Feb 1 2009 |
Externally published | Yes |
Keywords
- Clinical trial
- Phase I
- Prolongation
- Qt
- SR271425
- Thioxanthone
ASJC Scopus subject areas
- Oncology
- Cancer Research