A peptide inhibitor of luteinizing hormone releasing hormone (LH-RH)

D. H. Coy, J. A. Vilchez-Martinez, E. J. Coy, A. Arimura, Andrew V Schally

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Intracarotid infusion of des His 2 des Gly 10 LG RH ethylamide (pGlu Trp Ser Tyr Gly Leu Arg Pro NH CH 2 CH 3), an analog of LH-RH, into estrogen progesterone pretreated rats, effectively blocked responses to subsequent intravenous injections of LH-RH. The octapeptide antagonist itself possessed only minimal LH releasing activity.

Original languageEnglish
Pages (from-to)331-333
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume37
Issue number2
StatePublished - Dec 1 1973
Externally publishedYes

Fingerprint

Gonadotropin-Releasing Hormone
Peptides
Intravenous Injections
Progesterone
Rats
Estrogens
decaglycine
pyroglutamyltryptophan

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

A peptide inhibitor of luteinizing hormone releasing hormone (LH-RH). / Coy, D. H.; Vilchez-Martinez, J. A.; Coy, E. J.; Arimura, A.; Schally, Andrew V.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 37, No. 2, 01.12.1973, p. 331-333.

Research output: Contribution to journalArticle

Coy, DH, Vilchez-Martinez, JA, Coy, EJ, Arimura, A & Schally, AV 1973, 'A peptide inhibitor of luteinizing hormone releasing hormone (LH-RH)', Journal of Clinical Endocrinology and Metabolism, vol. 37, no. 2, pp. 331-333.
Coy, D. H. ; Vilchez-Martinez, J. A. ; Coy, E. J. ; Arimura, A. ; Schally, Andrew V. / A peptide inhibitor of luteinizing hormone releasing hormone (LH-RH). In: Journal of Clinical Endocrinology and Metabolism. 1973 ; Vol. 37, No. 2. pp. 331-333.
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