A peptide inhibitor of luteinizing hormone-releasing hormone (LH-RH)

David H. Coy, Jesus A. Vilchez-Martinez, Esther J. Coy, Akira Arimura, Andrew V. Schally

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Intracarotid infusion of des His 2 des Gly 10 LG RH ethylamide (pGlu Trp Ser Tyr Gly Leu Arg Pro NH CH 2 CH 3), an analog of LH-RH, into estrogen progesterone pretreated rats, effectively blocked responses to subsequent intravenous injections of LH-RH. The octapeptide antagonist itself possessed only minimal LH releasing activity.

Original languageEnglish (US)
Pages (from-to)331-333
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume37
Issue number2
DOIs
StatePublished - Aug 1973
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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