A patient with chronic hepatitis B and regression of fibrosis during treatment

Charissa Y. Chang, Paul Martin, Anastasia Fotiadu, Prodromos Hytiroglou

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

We present a patient with HBeAg-negative chronic hepatitis B, in whom significant regression of hepatic fibrosis was achieved after a lengthy antiviral treatment. A liver biopsy specimen obtained at initiation of treatment showed chronic hepatitis B with mild activity (histologic activity index: 7) and marked fibrosis (stage 4, in a scale of 0 to 6). A second biopsy specimen, obtained 10 years later, demonstrated almost complete resolution of necroinflammatory activity and fibrosis. One year after the second biopsy, seroconversion from HBsAg positive to anti-HBs positive status was achieved, and antiviral treatment was discontinued. This case is illustrative of the significant histologic improvement that can be accomplished in chronic hepatitis B when viral activity is suppressed long term. Lengthy antiviral treatment can achieve resorption of excess fibrous tissue, even in patients with marked fibrosis.

Original languageEnglish (US)
Pages (from-to)296-301
Number of pages6
JournalSeminars in liver disease
Volume30
Issue number3
DOIs
StatePublished - Aug 2 2010

Keywords

  • Chronic hepatitis B
  • HBsAg seroconversion
  • regression of fibrosis

ASJC Scopus subject areas

  • Hepatology

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