A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia

Izidore Lossos, Vered Bogomolski-Yahalome, Orly Yehuda, Susana Ben-Neriah, Dina Ben-Yehuda, Rachel Leizerowitz, Aaron Polliack

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A novel and as yet unrecorded translocation, (1;2)(p34;p21-22), detected in a patient with acute myeloid leukemia (AML) is reported. The leukemia-in this case, AML-M4-showed a rapidly progressive fatal course despite an early transient response to aggressive chemotherapy. In this patient, the leukemic cells showed a novel balanced translocation, (1;2)(p34;p21-22), in most of the metaphases at the time of diagnosis and during subsequent relapse. Interferon-inducible double-stranded RNA-dependent protein kinase (ds RNA- PK) is located in the chromosome region, 2p21-22, that was involved in the translocation in this case. The possible role of ds RNA-PK in leukemogenesis is briefly mentioned.

Original languageEnglish
Pages (from-to)78-79
Number of pages2
JournalCancer Genetics and Cytogenetics
Volume106
Issue number1
DOIs
StatePublished - Oct 1 1998
Externally publishedYes

Fingerprint

Leukemia
Leukemia, Myelomonocytic, Acute
eIF-2 Kinase
Double-Stranded RNA
Metaphase
Acute Myeloid Leukemia
Interferons
Chromosomes
RNA
Recurrence
Drug Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Lossos, I., Bogomolski-Yahalome, V., Yehuda, O., Ben-Neriah, S., Ben-Yehuda, D., Leizerowitz, R., & Polliack, A. (1998). A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia. Cancer Genetics and Cytogenetics, 106(1), 78-79. https://doi.org/10.1016/S0165-4608(98)00035-1

A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia. / Lossos, Izidore; Bogomolski-Yahalome, Vered; Yehuda, Orly; Ben-Neriah, Susana; Ben-Yehuda, Dina; Leizerowitz, Rachel; Polliack, Aaron.

In: Cancer Genetics and Cytogenetics, Vol. 106, No. 1, 01.10.1998, p. 78-79.

Research output: Contribution to journalArticle

Lossos, I, Bogomolski-Yahalome, V, Yehuda, O, Ben-Neriah, S, Ben-Yehuda, D, Leizerowitz, R & Polliack, A 1998, 'A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia', Cancer Genetics and Cytogenetics, vol. 106, no. 1, pp. 78-79. https://doi.org/10.1016/S0165-4608(98)00035-1
Lossos I, Bogomolski-Yahalome V, Yehuda O, Ben-Neriah S, Ben-Yehuda D, Leizerowitz R et al. A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia. Cancer Genetics and Cytogenetics. 1998 Oct 1;106(1):78-79. https://doi.org/10.1016/S0165-4608(98)00035-1
Lossos, Izidore ; Bogomolski-Yahalome, Vered ; Yehuda, Orly ; Ben-Neriah, Susana ; Ben-Yehuda, Dina ; Leizerowitz, Rachel ; Polliack, Aaron. / A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia. In: Cancer Genetics and Cytogenetics. 1998 ; Vol. 106, No. 1. pp. 78-79.
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