A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia

Izidore S. Lossos, Vered Bogomolski-Yahalome, Orly Yehuda, Susana Ben-Neriah, Dina Ben-Yehuda, Rachel Leizerowitz, Aaron Polliack

Research output: Contribution to journalArticle

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Abstract

A novel and as yet unrecorded translocation, (1;2)(p34;p21-22), detected in a patient with acute myeloid leukemia (AML) is reported. The leukemia-in this case, AML-M4-showed a rapidly progressive fatal course despite an early transient response to aggressive chemotherapy. In this patient, the leukemic cells showed a novel balanced translocation, (1;2)(p34;p21-22), in most of the metaphases at the time of diagnosis and during subsequent relapse. Interferon-inducible double-stranded RNA-dependent protein kinase (ds RNA- PK) is located in the chromosome region, 2p21-22, that was involved in the translocation in this case. The possible role of ds RNA-PK in leukemogenesis is briefly mentioned.

Original languageEnglish (US)
Pages (from-to)78-79
Number of pages2
JournalCancer Genetics and Cytogenetics
Volume106
Issue number1
DOIs
StatePublished - Oct 1 1998
Externally publishedYes

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ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Lossos, I. S., Bogomolski-Yahalome, V., Yehuda, O., Ben-Neriah, S., Ben-Yehuda, D., Leizerowitz, R., & Polliack, A. (1998). A novel translocation (1;2)(p34;p21-22) in acute myelomonoblastic leukemia. Cancer Genetics and Cytogenetics, 106(1), 78-79. https://doi.org/10.1016/S0165-4608(98)00035-1