A novel topical wound therapy delivery system

Ingrid Herskovitz, Flor E. MacQuhae, Luis J. Borda, Stephanie Bhagwandin, Juan A. Paredes, Thais Polanco, John C. Lantis, Paul J. Kim, Tania J. Phillips, Robert S. Kirsner

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction. Wound care dressings have evolved over time, from bandaging to the development of occlusive dressings to negative pressure wound therapy. A novel therapeutic delivery system dressing has been cleared by the United States Food and Drug Administration. This semi occlusive wound dressing has been developed to provide local, continuous delivery of aqueous topical agents, such as therapeutics (anesthetics, antiseptics, antibiotics, steroids, topical beta-blockers, immune modulatory agents, growth factors, and fibrinolytic agents, among others), at a rate of about ¾ mL per day, thus maintaining a hydrated environment and providing topical treatment. This type of system may be beneficial in situations where systemic therapies cannot be used, wounds are small and few, wounds may need frequent application of medication or moisture, or low and steady delivery of medications is needed. Objective. The authors assessed a delivery system dressing with different types of liquid medications for the management of hard-to-heal, chronic lower extremity wounds. Materials and Methods. Patients aged ≥ 18 and ≤ 90 years with stalled chronic wounds > 30 days' duration were selected for the use of a topical delivery system, which consists of a semi occlusive wound dressing and fluid delivery unit that can provide local application of small therapeutic quantities of medication directly to the wound. Results. Several successful cases with the use of this device are presented in which pain relief, enhancement of epithelial migration, inflammation reduction, bacterial control, and wound size reduction were achieved. Conclusions. This delivery system dressing is an effective and safe treatment option for wounds. Advantages include reduced potential of systemic side effects, flexibility in what can be delivered, constant rate of medication delivery, and convenience.

Original languageEnglish (US)
Pages (from-to)269-276
Number of pages8
JournalWounds
Volume29
Issue number9
StatePublished - Sep 1 2017

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Wounds and Injuries
Occlusive Dressings
Bandages
Therapeutics
Negative-Pressure Wound Therapy
Local Anti-Infective Agents
Fibrinolytic Agents
United States Food and Drug Administration
Anesthetics
Lower Extremity
Intercellular Signaling Peptides and Proteins
Steroids
Anti-Bacterial Agents
Inflammation
Pain
Equipment and Supplies

Keywords

  • Negative pressure wound therapy
  • Topical delivery system
  • Wound dressing
  • Wound irrigation

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical

Cite this

Herskovitz, I., MacQuhae, F. E., Borda, L. J., Bhagwandin, S., Paredes, J. A., Polanco, T., ... Kirsner, R. S. (2017). A novel topical wound therapy delivery system. Wounds, 29(9), 269-276.

A novel topical wound therapy delivery system. / Herskovitz, Ingrid; MacQuhae, Flor E.; Borda, Luis J.; Bhagwandin, Stephanie; Paredes, Juan A.; Polanco, Thais; Lantis, John C.; Kim, Paul J.; Phillips, Tania J.; Kirsner, Robert S.

In: Wounds, Vol. 29, No. 9, 01.09.2017, p. 269-276.

Research output: Contribution to journalArticle

Herskovitz, I, MacQuhae, FE, Borda, LJ, Bhagwandin, S, Paredes, JA, Polanco, T, Lantis, JC, Kim, PJ, Phillips, TJ & Kirsner, RS 2017, 'A novel topical wound therapy delivery system', Wounds, vol. 29, no. 9, pp. 269-276.
Herskovitz I, MacQuhae FE, Borda LJ, Bhagwandin S, Paredes JA, Polanco T et al. A novel topical wound therapy delivery system. Wounds. 2017 Sep 1;29(9):269-276.
Herskovitz, Ingrid ; MacQuhae, Flor E. ; Borda, Luis J. ; Bhagwandin, Stephanie ; Paredes, Juan A. ; Polanco, Thais ; Lantis, John C. ; Kim, Paul J. ; Phillips, Tania J. ; Kirsner, Robert S. / A novel topical wound therapy delivery system. In: Wounds. 2017 ; Vol. 29, No. 9. pp. 269-276.
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