TY - JOUR
T1 - A novel topical formulation containing strontium chloride signifcantly reduces the intensity and duration of cowhage-induced itch
AU - Papoiu, Alexandru D.P.
AU - Valdes-Rodriguez, Rodrigo
AU - Nattkemper, Leigh A.
AU - Chan, Yiong Huak
AU - Hahn, Gary S.
AU - Yosipovitch, Gil
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - The aim of this double-blinded, vehicle-controlled study was to test the antipruritic effcacy of topical strontium to relieve a nonhistaminergic form of itch that would be clinically relevant for chronic pruritic diseases. Itch induced with cowhage is mediated by PAR2 receptors which are considered to play a major role in itch of atopic dermatitis and possibly other acute and chronic pruritic conditions. The topical strontium hydrogel formulation (TriCalm®) was tested in a head-to-head comparison with 2 common topical formulations marketed as antipru-ritics: hydrocortisone and diphenhydramine, for their ability to relieve cowhage-induced itch. Topically-applied strontium salts were previously found to be effective for reducing histamine-induced and IgE-mediated itch in humans. However, histamine is not considered the critical mediator in the majority of skin diseases presenting with chronic pruritus. The current study enrolled 32 healthy subjects in which itch was induced with cowhage before and after skin treatment with a gel containing 4% SrCl2, control vehicle, topical 1% hydrocortisone and topical 2% diphenhydramine. Strontium signifcantly reduced the peak intensity and duration of cowhage-induced itch when compared to the control itch curve, and was signif-cantly superior to the other two over-the-counter antipru-ritic agents and its own vehicle in antipruritic effect. We hereby show that a 4% topical strontium formulation has a robust antipruritic effect, not only against histamine-mediated itch, but also for non-histaminergic pruritus induced via the PAR2 pathway, using cowhage.
AB - The aim of this double-blinded, vehicle-controlled study was to test the antipruritic effcacy of topical strontium to relieve a nonhistaminergic form of itch that would be clinically relevant for chronic pruritic diseases. Itch induced with cowhage is mediated by PAR2 receptors which are considered to play a major role in itch of atopic dermatitis and possibly other acute and chronic pruritic conditions. The topical strontium hydrogel formulation (TriCalm®) was tested in a head-to-head comparison with 2 common topical formulations marketed as antipru-ritics: hydrocortisone and diphenhydramine, for their ability to relieve cowhage-induced itch. Topically-applied strontium salts were previously found to be effective for reducing histamine-induced and IgE-mediated itch in humans. However, histamine is not considered the critical mediator in the majority of skin diseases presenting with chronic pruritus. The current study enrolled 32 healthy subjects in which itch was induced with cowhage before and after skin treatment with a gel containing 4% SrCl2, control vehicle, topical 1% hydrocortisone and topical 2% diphenhydramine. Strontium signifcantly reduced the peak intensity and duration of cowhage-induced itch when compared to the control itch curve, and was signif-cantly superior to the other two over-the-counter antipru-ritic agents and its own vehicle in antipruritic effect. We hereby show that a 4% topical strontium formulation has a robust antipruritic effect, not only against histamine-mediated itch, but also for non-histaminergic pruritus induced via the PAR2 pathway, using cowhage.
KW - Cowhage itch
KW - Strontium hydrogel
KW - Topical antipruritic
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U2 - 10.2340/00015555-1564
DO - 10.2340/00015555-1564
M3 - Article
C2 - 23474847
AN - SCOPUS:84883468280
VL - 93
SP - 520
EP - 524
JO - Acta Dermato-Venereologica
JF - Acta Dermato-Venereologica
SN - 0001-5555
IS - 5
ER -