A novel tetrode microdrive for simultaneous multi-neuron recording from different regions of primate brain

Lucas Santos, Ioan Opris, Joshua Fuqua, Robert E. Hampson, Sam A. Deadwyler

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A unique custom-made tetrode microdrive for recording from large numbers of neurons in several areas of primate brain is described as a means for assessing simultaneous neural activity in cortical and subcortical structures in nonhuman primates (NHPs) performing behavioral tasks. The microdrive device utilizes tetrode technology with up to six ultra-thin microprobe guide tubes (0.1. mm) that can be independently positioned, each containing reduced diameter tetrode and/or hexatrode microwires (0.02. mm) for recording and isolating single neuron activity. The microdrive device is mounted within the standard NHP cranial well and allows traversal of brain depths up to 40.0. mm. The advantages of this technology are demonstrated via simultaneously recorded large populations of neurons with tetrode type probes during task performance from a) primary motor cortex and deep brain structures (caudate-putamen and hippocampus) and b) multiple layers within the prefrontal cortex. The means to characterize interactions of well-isolated ensembles of neurons recorded simultaneously from different regions, as shown with this device, has not been previously available for application in primate brain. The device has extensive application to primate models for the detection and study of inoperative or maladaptive neural circuits related to human neurological disorders.

Original languageEnglish (US)
Pages (from-to)368-374
Number of pages7
JournalJournal of Neuroscience Methods
Volume205
Issue number2
DOIs
StatePublished - Apr 15 2012
Externally publishedYes

Fingerprint

Primates
Neurons
Brain
Equipment and Supplies
Technology
Putamen
Motor Cortex
Task Performance and Analysis
Prefrontal Cortex
Nervous System Diseases
Hippocampus
Population

Keywords

  • Motor cortex and striatum
  • Multi brain areas
  • New technologies and innovations
  • Simultaneous recordings
  • Tetrode for monkey

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A novel tetrode microdrive for simultaneous multi-neuron recording from different regions of primate brain. / Santos, Lucas; Opris, Ioan; Fuqua, Joshua; Hampson, Robert E.; Deadwyler, Sam A.

In: Journal of Neuroscience Methods, Vol. 205, No. 2, 15.04.2012, p. 368-374.

Research output: Contribution to journalArticle

Santos, Lucas ; Opris, Ioan ; Fuqua, Joshua ; Hampson, Robert E. ; Deadwyler, Sam A. / A novel tetrode microdrive for simultaneous multi-neuron recording from different regions of primate brain. In: Journal of Neuroscience Methods. 2012 ; Vol. 205, No. 2. pp. 368-374.
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