A novel strategy for quantifying choriocapillaris flow voids using swept-source OCT angiography

Qinqin Zhang, Fang Zheng, Elie H. Motulsky, Giovanni Gregori, Zhongdi Chu, Chieh Li Chen, Chunxia Li, Luis De Sisternes, Mary Durbin, Philip J Rosenfeld, Ruikang K. Wang

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

PURPOSE. To achieve reproducible imaging of the choriocapillaris and associated flow voids using swept-source OCT angiography (SS-OCTA). METHODS. Subjects were enrolled and SS-OCTA was performed using the 3 × 3 mm scan pattern. Blood flow was identified using the complex optical microangiography (OMAG) algorithm. The choriocapillaris was defined as a slab from the outer boundary of Bruch’s membrane (BM) to approximately 20 lm below BM. Compensation for the shadowing effect caused by the RPE and BM complex on the choriocapillaris angiogram was achieved by using the structural information from the same slab. A thresholding method to calculate the percentage of flow voids from a region was developed based on a normal database. RESULTS. Twenty normal subjects and 12 subjects with drusen were enrolled. SS-OCTA identified the choriocapillaris in normal subjects as a lobular plexus of capillaries in the central macula and the lobular arrangement became more evident toward the periphery. In all eyes, signal compensation resulted in fewer choriocapillaris flow voids with improved repeatability of measurements. The best repeatability for the measurement was achieved by using 1 standard deviation (SD) for the thresholding strategy. CONCLUSIONS. SS-OCTA can image the choriocapillaris in vivo, and the repeatability of flow void measurements is high in the presence of drusen. The ability to image the choriocapillaris and associated flow voids should prove useful in understanding disease onset, progression, and response to therapies.

Original languageEnglish (US)
Pages (from-to)203-211
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Volume59
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Bruch Membrane
Angiography
Disease Progression
Databases
Therapeutics

Keywords

  • Choriocapillaris
  • Flow voids
  • OCTA
  • Optical coherence tomography angiography
  • Swept-source OCTA

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

A novel strategy for quantifying choriocapillaris flow voids using swept-source OCT angiography. / Zhang, Qinqin; Zheng, Fang; Motulsky, Elie H.; Gregori, Giovanni; Chu, Zhongdi; Chen, Chieh Li; Li, Chunxia; De Sisternes, Luis; Durbin, Mary; Rosenfeld, Philip J; Wang, Ruikang K.

In: Investigative Ophthalmology and Visual Science, Vol. 59, No. 1, 01.01.2018, p. 203-211.

Research output: Contribution to journalArticle

Zhang, Q, Zheng, F, Motulsky, EH, Gregori, G, Chu, Z, Chen, CL, Li, C, De Sisternes, L, Durbin, M, Rosenfeld, PJ & Wang, RK 2018, 'A novel strategy for quantifying choriocapillaris flow voids using swept-source OCT angiography', Investigative Ophthalmology and Visual Science, vol. 59, no. 1, pp. 203-211. https://doi.org/10.1167/iovs.17-22953
Zhang, Qinqin ; Zheng, Fang ; Motulsky, Elie H. ; Gregori, Giovanni ; Chu, Zhongdi ; Chen, Chieh Li ; Li, Chunxia ; De Sisternes, Luis ; Durbin, Mary ; Rosenfeld, Philip J ; Wang, Ruikang K. / A novel strategy for quantifying choriocapillaris flow voids using swept-source OCT angiography. In: Investigative Ophthalmology and Visual Science. 2018 ; Vol. 59, No. 1. pp. 203-211.
@article{d9175dd9dcac4ee48c70898a6bc4542f,
title = "A novel strategy for quantifying choriocapillaris flow voids using swept-source OCT angiography",
abstract = "PURPOSE. To achieve reproducible imaging of the choriocapillaris and associated flow voids using swept-source OCT angiography (SS-OCTA). METHODS. Subjects were enrolled and SS-OCTA was performed using the 3 × 3 mm scan pattern. Blood flow was identified using the complex optical microangiography (OMAG) algorithm. The choriocapillaris was defined as a slab from the outer boundary of Bruch’s membrane (BM) to approximately 20 lm below BM. Compensation for the shadowing effect caused by the RPE and BM complex on the choriocapillaris angiogram was achieved by using the structural information from the same slab. A thresholding method to calculate the percentage of flow voids from a region was developed based on a normal database. RESULTS. Twenty normal subjects and 12 subjects with drusen were enrolled. SS-OCTA identified the choriocapillaris in normal subjects as a lobular plexus of capillaries in the central macula and the lobular arrangement became more evident toward the periphery. In all eyes, signal compensation resulted in fewer choriocapillaris flow voids with improved repeatability of measurements. The best repeatability for the measurement was achieved by using 1 standard deviation (SD) for the thresholding strategy. CONCLUSIONS. SS-OCTA can image the choriocapillaris in vivo, and the repeatability of flow void measurements is high in the presence of drusen. The ability to image the choriocapillaris and associated flow voids should prove useful in understanding disease onset, progression, and response to therapies.",
keywords = "Choriocapillaris, Flow voids, OCTA, Optical coherence tomography angiography, Swept-source OCTA",
author = "Qinqin Zhang and Fang Zheng and Motulsky, {Elie H.} and Giovanni Gregori and Zhongdi Chu and Chen, {Chieh Li} and Chunxia Li and {De Sisternes}, Luis and Mary Durbin and Rosenfeld, {Philip J} and Wang, {Ruikang K.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1167/iovs.17-22953",
language = "English (US)",
volume = "59",
pages = "203--211",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "1",

}

TY - JOUR

T1 - A novel strategy for quantifying choriocapillaris flow voids using swept-source OCT angiography

AU - Zhang, Qinqin

AU - Zheng, Fang

AU - Motulsky, Elie H.

AU - Gregori, Giovanni

AU - Chu, Zhongdi

AU - Chen, Chieh Li

AU - Li, Chunxia

AU - De Sisternes, Luis

AU - Durbin, Mary

AU - Rosenfeld, Philip J

AU - Wang, Ruikang K.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - PURPOSE. To achieve reproducible imaging of the choriocapillaris and associated flow voids using swept-source OCT angiography (SS-OCTA). METHODS. Subjects were enrolled and SS-OCTA was performed using the 3 × 3 mm scan pattern. Blood flow was identified using the complex optical microangiography (OMAG) algorithm. The choriocapillaris was defined as a slab from the outer boundary of Bruch’s membrane (BM) to approximately 20 lm below BM. Compensation for the shadowing effect caused by the RPE and BM complex on the choriocapillaris angiogram was achieved by using the structural information from the same slab. A thresholding method to calculate the percentage of flow voids from a region was developed based on a normal database. RESULTS. Twenty normal subjects and 12 subjects with drusen were enrolled. SS-OCTA identified the choriocapillaris in normal subjects as a lobular plexus of capillaries in the central macula and the lobular arrangement became more evident toward the periphery. In all eyes, signal compensation resulted in fewer choriocapillaris flow voids with improved repeatability of measurements. The best repeatability for the measurement was achieved by using 1 standard deviation (SD) for the thresholding strategy. CONCLUSIONS. SS-OCTA can image the choriocapillaris in vivo, and the repeatability of flow void measurements is high in the presence of drusen. The ability to image the choriocapillaris and associated flow voids should prove useful in understanding disease onset, progression, and response to therapies.

AB - PURPOSE. To achieve reproducible imaging of the choriocapillaris and associated flow voids using swept-source OCT angiography (SS-OCTA). METHODS. Subjects were enrolled and SS-OCTA was performed using the 3 × 3 mm scan pattern. Blood flow was identified using the complex optical microangiography (OMAG) algorithm. The choriocapillaris was defined as a slab from the outer boundary of Bruch’s membrane (BM) to approximately 20 lm below BM. Compensation for the shadowing effect caused by the RPE and BM complex on the choriocapillaris angiogram was achieved by using the structural information from the same slab. A thresholding method to calculate the percentage of flow voids from a region was developed based on a normal database. RESULTS. Twenty normal subjects and 12 subjects with drusen were enrolled. SS-OCTA identified the choriocapillaris in normal subjects as a lobular plexus of capillaries in the central macula and the lobular arrangement became more evident toward the periphery. In all eyes, signal compensation resulted in fewer choriocapillaris flow voids with improved repeatability of measurements. The best repeatability for the measurement was achieved by using 1 standard deviation (SD) for the thresholding strategy. CONCLUSIONS. SS-OCTA can image the choriocapillaris in vivo, and the repeatability of flow void measurements is high in the presence of drusen. The ability to image the choriocapillaris and associated flow voids should prove useful in understanding disease onset, progression, and response to therapies.

KW - Choriocapillaris

KW - Flow voids

KW - OCTA

KW - Optical coherence tomography angiography

KW - Swept-source OCTA

UR - http://www.scopus.com/inward/record.url?scp=85040928662&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040928662&partnerID=8YFLogxK

U2 - 10.1167/iovs.17-22953

DO - 10.1167/iovs.17-22953

M3 - Article

C2 - 29340648

AN - SCOPUS:85040928662

VL - 59

SP - 203

EP - 211

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 1

ER -