A novel strategy for quantifying choriocapillaris flow voids using swept-source OCT angiography

Qinqin Zhang, Fang Zheng, Elie H. Motulsky, Giovanni Gregori, Zhongdi Chu, Chieh Li Chen, Chunxia Li, Luis De Sisternes, Mary Durbin, Philip J. Rosenfeld, Ruikang K. Wang

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


PURPOSE. To achieve reproducible imaging of the choriocapillaris and associated flow voids using swept-source OCT angiography (SS-OCTA). METHODS. Subjects were enrolled and SS-OCTA was performed using the 3 × 3 mm scan pattern. Blood flow was identified using the complex optical microangiography (OMAG) algorithm. The choriocapillaris was defined as a slab from the outer boundary of Bruch’s membrane (BM) to approximately 20 lm below BM. Compensation for the shadowing effect caused by the RPE and BM complex on the choriocapillaris angiogram was achieved by using the structural information from the same slab. A thresholding method to calculate the percentage of flow voids from a region was developed based on a normal database. RESULTS. Twenty normal subjects and 12 subjects with drusen were enrolled. SS-OCTA identified the choriocapillaris in normal subjects as a lobular plexus of capillaries in the central macula and the lobular arrangement became more evident toward the periphery. In all eyes, signal compensation resulted in fewer choriocapillaris flow voids with improved repeatability of measurements. The best repeatability for the measurement was achieved by using 1 standard deviation (SD) for the thresholding strategy. CONCLUSIONS. SS-OCTA can image the choriocapillaris in vivo, and the repeatability of flow void measurements is high in the presence of drusen. The ability to image the choriocapillaris and associated flow voids should prove useful in understanding disease onset, progression, and response to therapies.

Original languageEnglish (US)
Pages (from-to)203-211
Number of pages9
JournalInvestigative Ophthalmology and Visual Science
Issue number1
StatePublished - Jan 2018


  • Choriocapillaris
  • Flow voids
  • OCTA
  • Optical coherence tomography angiography
  • Swept-source OCTA

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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