A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells

Hitoshi Nishimura, Toshiki Yajima, Hiromi Muta, Eckhard R. Podack, Kenzaburo Tani, Yasunobu Yoshikai

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Memory CD8+ T cells can be divided into two subsets, central memory (TCM) and effector memory (TEM) CD8+ T cells. We foend that CD30, a member of the TNFR-associated factor (TRAF)-linked TNFR seperfamily, signaling is involved in differentiation of long-lived CD8+ TCM cells following Listeria monocytogenes infection. Although CD8+ TEM cells transiently accumulated in the noalymphoid tissues of CD30 ligand (CD153-/-) mice after infection, long-lived memory CD8+ TCM cells were poorly generated in these mice. CCR7 mRNA expression was down-regulated in CD8+ T cells of the spleen of CD153-/- mice in vivo and the expression was up-regulated in CD8+ TEM cells by anti-CD30 mAb cross-linking in vitro. These results suggest that CD30/CD30 ligand signaling plays an important role in the generation of long-lived memory CD8+ T cells at least partly by triggering homing receptors for TCM cells.

Original languageEnglish (US)
Pages (from-to)4627-4634
Number of pages8
JournalJournal of Immunology
Volume175
Issue number7
DOIs
StatePublished - Oct 1 2005

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Nishimura, H., Yajima, T., Muta, H., Podack, E. R., Tani, K., & Yoshikai, Y. (2005). A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells. Journal of Immunology, 175(7), 4627-4634. https://doi.org/10.4049/jimmunol.175.7.4627