A novel rat model for chemotherapy-induced alopecia

T. C. Wikramanayake, S. Amini, J. Simon, L. M. Mauro, G. Elgart, L. A. Schachner, J. J. Jimenez

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background. More than half of all people diagnosed with cancer receive chemotherapy, and approximately 65% of these develop chemotherapy-induced alopecia (CIA), a side-effect that can have considerable negative psychological repercussions. Currently, there are very few animal models available to study the mechanism and prevention of CIA. Aim. To develop a clinically relevant adult rat model for CIA. Methods. We first tested whether neonatal pigmented Long-Evans (LE) rats developed alopecia in response to the chemotherapeutic agents etoposide and cyclophosphamide. We then determined whether the rats developed CIA as adults. In the latter experiment, rat dorsal hair was clipped during the early telogen stage to synchronize the hair cycle, and starting 15 days later, the rats were treated with etoposide for 3 days. Results. Neonatal LE pups developed CIA in response to etoposide and cyclophosphamide, similar to other murine models for CIA. Clipping of the hair shaft during early telogen resulted in synchronized anagen induction and subsequent alopecia after etoposide treatment in the clipped areas only. Hair follicles in the clipped areas had the typical chemotherapy-induced follicular dystrophy (dystrophic catagen). When the hair in the pigmented alopecic areas regrew, it had normal pigmentation. Conclusions. A novel, pigmented adult rat model has been established for CIA. By hair-shaft clipping during early telogen, synchronized anagen entry was induced, which resulted in alopecia in response to chemotherapy. This is the first clinically relevant adult rat model for CIA, and will be a useful tool to test agents for the prevention and treatment of CIA.

Original languageEnglish (US)
Pages (from-to)284-289
Number of pages6
JournalClinical and Experimental Dermatology
Volume37
Issue number3
DOIs
StatePublished - Apr 1 2012

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'A novel rat model for chemotherapy-induced alopecia'. Together they form a unique fingerprint.

  • Cite this