A novel phosphotransferase system of Streptococcus mutans is responsible for transport of carbohydrates with α-1,3 linkage

D. Ajdic, Z. Chen

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The most common type of carbohydrate-transport system in Streptococcus mutans is the phosphoenolpyruvate-sugar phosphotransferase system (PTS). Fourteen PTS exist in S. mutans UA159. Several studies have shown that microorganisms growing in biofilms express different genes compared with their planktonic counterparts. In this study, we showed that one PTS of S. mutans was expressed in sucrose-grown biofilms. Furthermore, the same PTS was also responsible for the transport and metabolism of disaccharide nigerose (3-O-α-d-glucopyranosyl-d-glucose). Additionally, the results indicate that the studied PTS might be involved in the transport and metabolism of carbohydrates synthesized by glucosyltransferase B and glucosyltransferase C of S. mutans. To our knowledge, this is the first report that shows PTS transport of a disaccharide (and possibly extracellular oligosaccharides) with α-1,3 linkage.

Original languageEnglish (US)
Pages (from-to)114-128
Number of pages15
JournalMolecular Oral Microbiology
Volume28
Issue number2
DOIs
StatePublished - Apr 2013

Keywords

  • Biofilm
  • Carbohydrate
  • Microarray
  • Streptococcus mutans
  • Transporter

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Microbiology (medical)
  • Dentistry(all)

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