A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells

Attan Kasid, Jeannine S. Strobl, Karen Huff, Geoffrey L. Greene, Marc E. Lippman

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Nuclear estrogen receptor from MCF-7 cells undergoes a time-dependent, hormone-inducible transformation to a form that is less extractable from nuclei and less exchangeable with ligand. This receptor-modifying, intranuclear event is independent of receptor loss (processing) and appears associated with hormone responsiveness (progesterone-receptor induction) in these cells. The magnitude of receptor loss, however, is variable and apparently not a prerequisite for hormone action to induce progesterone receptor.

Original languageEnglish (US)
Pages (from-to)1162-1165
Number of pages4
JournalScience
Volume225
Issue number4667
DOIs
StatePublished - Jan 1 1984

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Kasid, A., Strobl, J. S., Huff, K., Greene, G. L., & Lippman, M. E. (1984). A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells. Science, 225(4667), 1162-1165. https://doi.org/10.1126/science.6474170