A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells

A. Kasid, J. S. Strobl, K. Huff, G. L. Greene, Marc E Lippman

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Nuclear estrogen receptor from MCF-7 cells undergoes a time-dependent, hormone-inducible transformation to a form that is less extractable from nuclei and less exchangeable with ligand. This receptor-modifying, intranuclear event is independent of receptor loss (processing) and appears associated with hormone responsiveness (progesterone-receptor induction) in these cells. The magnitude of receptor loss, however, is variable and apparently not a prerequisite for hormone action to induce progesterone receptor.

Original languageEnglish
Pages (from-to)1162-1165
Number of pages4
JournalScience
Volume225
Issue number4667
DOIs
StatePublished - Nov 1 1984
Externally publishedYes

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Estradiol Receptors
Hormones
Progesterone Receptors
Breast Neoplasms
MCF-7 Cells
Estrogen Receptors
Ligands

ASJC Scopus subject areas

  • General

Cite this

Kasid, A., Strobl, J. S., Huff, K., Greene, G. L., & Lippman, M. E. (1984). A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells. Science, 225(4667), 1162-1165. https://doi.org/10.1126/science.6474170

A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells. / Kasid, A.; Strobl, J. S.; Huff, K.; Greene, G. L.; Lippman, Marc E.

In: Science, Vol. 225, No. 4667, 01.11.1984, p. 1162-1165.

Research output: Contribution to journalArticle

Kasid, A, Strobl, JS, Huff, K, Greene, GL & Lippman, ME 1984, 'A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells', Science, vol. 225, no. 4667, pp. 1162-1165. https://doi.org/10.1126/science.6474170
Kasid A, Strobl JS, Huff K, Greene GL, Lippman ME. A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells. Science. 1984 Nov 1;225(4667):1162-1165. https://doi.org/10.1126/science.6474170
Kasid, A. ; Strobl, J. S. ; Huff, K. ; Greene, G. L. ; Lippman, Marc E. / A novel nuclear form of estradiol receptor in MCF-7 human breast cancer cells. In: Science. 1984 ; Vol. 225, No. 4667. pp. 1162-1165.
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