A novel locus for body mass index on 5p15.2: A meta-analysis of two genome-wide association studies

Ke Sheng Wang, Xuefeng Liu, Shimin Zheng, Min Zeng, Yue Pan, Katie Callahan

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Objective: Genetic factors play an important role in modulating the vulnerability to body mass index (BMI). The purpose of this study is to identify novel genetic variants for BMI using genome-wide association (GWA) meta-analysis. Methods: PLINK software was used to perform meta-analysis of two GWA studies (the FUSION and Marshfield samples) of 5218 Caucasian individuals with BMI. A replication study was conducted using the SAGE sample with 762 individuals. Results: Through meta-analysis we identified 33 SNPs associated with BMI with p<10 -4. The most significant association was observed with rs2967951 (p=1.19×10 -6) at 5p15.2 within ROPN1L gene. Two additional SNPs within ROPN1L and 5 SNPs within MARCH6 (the top SNP was rs2607292 with 4.27×10 -6) further supported the association with BMI on 5p15.2 (p<1.8×10 -5). Conditional analysis on 5p15.2 could not distinguish the effects of ROPN1L and MARCH6. Several SNPs within MARCH6 and ROPN1L were replicated in the SAGE sample (p<0.05). Conclusion: We identified a novel locus for BMI. These findings offer the potential for new insights into the pathogenesis of BMI and obesity and will serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in BMI and obesity.

Original languageEnglish (US)
Pages (from-to)80-84
Number of pages5
JournalGene
Volume500
Issue number1
DOIs
StatePublished - May 25 2012

Keywords

  • Body mass index
  • Genome-wide association
  • MARCH6
  • Meta-analysis
  • ROPN1L

ASJC Scopus subject areas

  • Genetics

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