A novel inexpensive murine model of oral chronic digitalization

Izo Helber, Rosemeire M. Kanashiro, Ernesto A. Alarcon, Ednei L. Antonio, Paulo J.F. Tucci

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

1. A novel inexpensive murine model of oral administration of digitoxin (100 μg/kg per day) added to routine chow is described. 2. Serum digitoxin levels achieved after oral (n = 5; 116 ± 14 ng/mL) and subcutaneous (n = 5; 124 ± 11 ng/mL) administration were similar. 3. A significant increase in the maximal left ventricular pressure rise of treated (n = 9) compared with control (n = 6) rats (dP/dt: 8956 ± 233 vs 7980 ± 234 mmHg/s, respectively; P = 0.01) characterized the positive inotropic action of digitoxin. In addition, no differences were observed in treated compared with control rats with regard to the electrocardiogram and systolic and diastolic left ventricular pressures.

Original languageEnglish (US)
Pages (from-to)365-366
Number of pages2
JournalClinical and Experimental Pharmacology and Physiology
Volume31
Issue number5-6
DOIs
StatePublished - May 1 2004
Externally publishedYes

Keywords

  • Chronic digitalization
  • Oral digitoxin
  • Rat

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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