A novel inert collagen matrix for hypospadias repair

Anthony Atala, Luis Guzman, Alan B. Retik

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

Purpose: In select patients with hypospadias in whom genital skin is insufficient alternative tissues are needed for urethral reconstruction. Although skin and mucosal grafts may be used, they may increase hospitalization and morbidity. We explored the feasibility of using a bladder submucosal, collagen based inert matrix as a free graft substitute for urethral repair. Materials and Methods: Four patients with a history of hypospadias underwent repeat hypospadias repair using a collagen based inert matrix for urethral reconstruction. The inert collagen matrix was trimmed to size as needed for each patient. The neourethra was created by anastomosing the matrix in an onlay fashion to the urethral plate with continuous 6-zero polyglactin sutures. The created neourethra size ranged from 5 to 15 cm. Results: After a 22-month followup 3 of the 4 patients had a successful outcome in regard to cosmesis and function. One patient in whom a 15 cm. neourethra was created had a subglanular fistula. Conclusions: The use of a collagen inert matrix appears to be beneficial in patients who have undergone previous hypospadias repair and who may lack sufficient genital skin for reconstruction.

Original languageEnglish
Pages (from-to)1148-1151
Number of pages4
JournalJournal of Urology
Volume162
Issue number3 II
DOIs
StatePublished - Sep 1 1999
Externally publishedYes

Fingerprint

Hypospadias
Collagen
Skin
Transplants
Polyglactin 910
Inlays
Sutures
Fistula
Urinary Bladder
Hospitalization
Morbidity

Keywords

  • Abnormalities
  • Collagen
  • Hypospadias
  • Penis
  • Urethra

ASJC Scopus subject areas

  • Urology

Cite this

A novel inert collagen matrix for hypospadias repair. / Atala, Anthony; Guzman, Luis; Retik, Alan B.

In: Journal of Urology, Vol. 162, No. 3 II, 01.09.1999, p. 1148-1151.

Research output: Contribution to journalArticle

Atala, A, Guzman, L & Retik, AB 1999, 'A novel inert collagen matrix for hypospadias repair', Journal of Urology, vol. 162, no. 3 II, pp. 1148-1151. https://doi.org/10.1016/S0022-5347(01)68105-9
Atala, Anthony ; Guzman, Luis ; Retik, Alan B. / A novel inert collagen matrix for hypospadias repair. In: Journal of Urology. 1999 ; Vol. 162, No. 3 II. pp. 1148-1151.
@article{ff50799c147448678bd091d064a2d7f6,
title = "A novel inert collagen matrix for hypospadias repair",
abstract = "Purpose: In select patients with hypospadias in whom genital skin is insufficient alternative tissues are needed for urethral reconstruction. Although skin and mucosal grafts may be used, they may increase hospitalization and morbidity. We explored the feasibility of using a bladder submucosal, collagen based inert matrix as a free graft substitute for urethral repair. Materials and Methods: Four patients with a history of hypospadias underwent repeat hypospadias repair using a collagen based inert matrix for urethral reconstruction. The inert collagen matrix was trimmed to size as needed for each patient. The neourethra was created by anastomosing the matrix in an onlay fashion to the urethral plate with continuous 6-zero polyglactin sutures. The created neourethra size ranged from 5 to 15 cm. Results: After a 22-month followup 3 of the 4 patients had a successful outcome in regard to cosmesis and function. One patient in whom a 15 cm. neourethra was created had a subglanular fistula. Conclusions: The use of a collagen inert matrix appears to be beneficial in patients who have undergone previous hypospadias repair and who may lack sufficient genital skin for reconstruction.",
keywords = "Abnormalities, Collagen, Hypospadias, Penis, Urethra",
author = "Anthony Atala and Luis Guzman and Retik, {Alan B.}",
year = "1999",
month = "9",
day = "1",
doi = "10.1016/S0022-5347(01)68105-9",
language = "English",
volume = "162",
pages = "1148--1151",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "3 II",

}

TY - JOUR

T1 - A novel inert collagen matrix for hypospadias repair

AU - Atala, Anthony

AU - Guzman, Luis

AU - Retik, Alan B.

PY - 1999/9/1

Y1 - 1999/9/1

N2 - Purpose: In select patients with hypospadias in whom genital skin is insufficient alternative tissues are needed for urethral reconstruction. Although skin and mucosal grafts may be used, they may increase hospitalization and morbidity. We explored the feasibility of using a bladder submucosal, collagen based inert matrix as a free graft substitute for urethral repair. Materials and Methods: Four patients with a history of hypospadias underwent repeat hypospadias repair using a collagen based inert matrix for urethral reconstruction. The inert collagen matrix was trimmed to size as needed for each patient. The neourethra was created by anastomosing the matrix in an onlay fashion to the urethral plate with continuous 6-zero polyglactin sutures. The created neourethra size ranged from 5 to 15 cm. Results: After a 22-month followup 3 of the 4 patients had a successful outcome in regard to cosmesis and function. One patient in whom a 15 cm. neourethra was created had a subglanular fistula. Conclusions: The use of a collagen inert matrix appears to be beneficial in patients who have undergone previous hypospadias repair and who may lack sufficient genital skin for reconstruction.

AB - Purpose: In select patients with hypospadias in whom genital skin is insufficient alternative tissues are needed for urethral reconstruction. Although skin and mucosal grafts may be used, they may increase hospitalization and morbidity. We explored the feasibility of using a bladder submucosal, collagen based inert matrix as a free graft substitute for urethral repair. Materials and Methods: Four patients with a history of hypospadias underwent repeat hypospadias repair using a collagen based inert matrix for urethral reconstruction. The inert collagen matrix was trimmed to size as needed for each patient. The neourethra was created by anastomosing the matrix in an onlay fashion to the urethral plate with continuous 6-zero polyglactin sutures. The created neourethra size ranged from 5 to 15 cm. Results: After a 22-month followup 3 of the 4 patients had a successful outcome in regard to cosmesis and function. One patient in whom a 15 cm. neourethra was created had a subglanular fistula. Conclusions: The use of a collagen inert matrix appears to be beneficial in patients who have undergone previous hypospadias repair and who may lack sufficient genital skin for reconstruction.

KW - Abnormalities

KW - Collagen

KW - Hypospadias

KW - Penis

KW - Urethra

UR - http://www.scopus.com/inward/record.url?scp=0032866412&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032866412&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(01)68105-9

DO - 10.1016/S0022-5347(01)68105-9

M3 - Article

VL - 162

SP - 1148

EP - 1151

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 3 II

ER -