Abstract
Low-renin hypertension responsive to amiloride-thiazide therapy in a 4-year-old Afro-Haitian girl suggested Liddle syndrome. Urine steroid profiling substantiated the diagnosis and DNA analysis of the epithelial sodium channel (ENaC) revealed a novel heterozygous βENaC mutation in the patient and in her hypertensive father. Liddle syndrome should be considered as a cause of hypertension in young children particularly with suppressed renin activity.
Original language | English (US) |
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Pages (from-to) | 512-515 |
Number of pages | 4 |
Journal | Pediatric Nephrology |
Volume | 20 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2005 |
Keywords
- Aldosterone
- Blood pressure
- Hypertension
- Hypokalemia
- Renin
ASJC Scopus subject areas
- Nephrology
- Pediatrics, Perinatology, and Child Health