A Novel Computerized Cognitive Stress Test to Detect Mild Cognitive Impairment

Rosie E. Curiel Cid, E. A. Crocco, M. Kitaigorodsky, L. Beaufils, P. A. Peña, G. Grau, U. Visser, D. A. Loewenstein

Research output: Contribution to journalArticlepeer-review


Background: The Loewenstein Acevedo Scales of Semantic Interference and Learning (LASSI-L) is a novel and increasingly employed instrument that has outperformed widely used cognitive measures as an early correlate of elevated brain amyloid and neurodegeneration in prodromal Alzheimer’s Disease (AD). The LASSI-L has distinguished those with amnestic mild cognitive impairment (aMCI) and high amyloid load from aMCI attributable to other non-AD conditions. The authors designed and implemented a web-based brief computerized version of the instrument, the LASSI-BC, to improve standardized administration, facilitate scoring accuracy, real-time data entry, and increase the accessibility of the measure. Objective: The psychometric properties and clinical utility of the brief computerized version of the LASSI-L was evaluated, together with its ability to differentiate older adults who are cognitively normal (CN) from those with amnestic Mild Cognitive Impairment (aMCI). Methods: After undergoing a comprehensive uniform clinical and neuropsychological evaluation using traditional measures, older adults were classified as cognitively normal or diagnosed with aMCI. All participants were administered the LASSI-BC, a computerized version of the LASSI-L. Test-retest and discriminant validity was assessed for each LASSI-BC subscale. RESULTS: LASSI-BC subscales demonstrated high test-retest reliability, and discriminant validity was attained. Conclusions: The LASSI-BC, a brief computerized version of the LASSI-L is a valid and useful cognitive tool for the detection of aMCI among older adults.

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
JournalThe journal of prevention of Alzheimer's disease
Issue number2
StatePublished - Feb 2021


  • Alzheimer–s disease
  • Computerized test
  • clinical trials
  • mild cognitive impairment
  • semantic interference
  • semantic intrusion errors

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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