TY - JOUR
T1 - A Novel Computerized Cognitive Stress Test to Detect Mild Cognitive Impairment
AU - Curiel Cid, Rosie E.
AU - Crocco, E. A.
AU - Kitaigorodsky, M.
AU - Beaufils, L.
AU - Peña, P. A.
AU - Grau, G.
AU - Visser, U.
AU - Loewenstein, D. A.
N1 - Funding Information:
Funding: This research was funded by the National Institute of Aging Grant 1 ROI AG047649-01A1 (David Loewenstein, PI), 1 ROI AG047649-01A1 (Rosie Curiel Cid, PI) 5 P50 AG047726602 1Florida Alzheimer’s Disease Research Center (Todd Golde, PI), 8AZ. The sponsors had no role in the design and conduct of the study; in the collection analysis, and interpretation of data; in the preparation of the manuscript; or in the review or approval of the manuscript.
Publisher Copyright:
© 2021, Serdi and Springer Nature Switzerland AG.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2
Y1 - 2021/2
N2 - Background: The Loewenstein Acevedo Scales of Semantic Interference and Learning (LASSI-L) is a novel and increasingly employed instrument that has outperformed widely used cognitive measures as an early correlate of elevated brain amyloid and neurodegeneration in prodromal Alzheimer’s Disease (AD). The LASSI-L has distinguished those with amnestic mild cognitive impairment (aMCI) and high amyloid load from aMCI attributable to other non-AD conditions. The authors designed and implemented a web-based brief computerized version of the instrument, the LASSI-BC, to improve standardized administration, facilitate scoring accuracy, real-time data entry, and increase the accessibility of the measure. Objective: The psychometric properties and clinical utility of the brief computerized version of the LASSI-L was evaluated, together with its ability to differentiate older adults who are cognitively normal (CN) from those with amnestic Mild Cognitive Impairment (aMCI). Methods: After undergoing a comprehensive uniform clinical and neuropsychological evaluation using traditional measures, older adults were classified as cognitively normal or diagnosed with aMCI. All participants were administered the LASSI-BC, a computerized version of the LASSI-L. Test-retest and discriminant validity was assessed for each LASSI-BC subscale. RESULTS: LASSI-BC subscales demonstrated high test-retest reliability, and discriminant validity was attained. Conclusions: The LASSI-BC, a brief computerized version of the LASSI-L is a valid and useful cognitive tool for the detection of aMCI among older adults.
AB - Background: The Loewenstein Acevedo Scales of Semantic Interference and Learning (LASSI-L) is a novel and increasingly employed instrument that has outperformed widely used cognitive measures as an early correlate of elevated brain amyloid and neurodegeneration in prodromal Alzheimer’s Disease (AD). The LASSI-L has distinguished those with amnestic mild cognitive impairment (aMCI) and high amyloid load from aMCI attributable to other non-AD conditions. The authors designed and implemented a web-based brief computerized version of the instrument, the LASSI-BC, to improve standardized administration, facilitate scoring accuracy, real-time data entry, and increase the accessibility of the measure. Objective: The psychometric properties and clinical utility of the brief computerized version of the LASSI-L was evaluated, together with its ability to differentiate older adults who are cognitively normal (CN) from those with amnestic Mild Cognitive Impairment (aMCI). Methods: After undergoing a comprehensive uniform clinical and neuropsychological evaluation using traditional measures, older adults were classified as cognitively normal or diagnosed with aMCI. All participants were administered the LASSI-BC, a computerized version of the LASSI-L. Test-retest and discriminant validity was assessed for each LASSI-BC subscale. RESULTS: LASSI-BC subscales demonstrated high test-retest reliability, and discriminant validity was attained. Conclusions: The LASSI-BC, a brief computerized version of the LASSI-L is a valid and useful cognitive tool for the detection of aMCI among older adults.
KW - Alzheimer–s disease
KW - Computerized test
KW - clinical trials
KW - mild cognitive impairment
KW - semantic interference
KW - semantic intrusion errors
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U2 - 10.14283/jpad.2021.1
DO - 10.14283/jpad.2021.1
M3 - Article
C2 - 33569559
AN - SCOPUS:85100577973
VL - 8
SP - 135
EP - 141
JO - The journal of prevention of Alzheimer's disease
JF - The journal of prevention of Alzheimer's disease
SN - 2426-0266
IS - 2
ER -