A Novel Approach to High-Quality Postmortem Tissue Procurement

The GTEx Project

Latarsha J. Carithers, Kristin Ardlie, Mary Barcus, Philip A. Branton, Angela Britton, Stephen A. Buia, Carolyn C. Compton, David S. Deluca, Joanne Peter-Demchok, Ellen T. Gelfand, Ping Guan, Greg E. Korzeniewski, Nicole C. Lockhart, Chana A. Rabiner, Abhi K. Rao, Karna L. Robinson, Nancy V. Roche, Sherilyn J. Sawyer, Ayellet V. Segrè, Charles E. Shive & 125 others Anna M. Smith, Leslie H. Sobin, Anita H. Undale, Kimberly M. Valentino, Jim Vaught, Taylor R. Young, Helen M. Moore, Laura Barker, Margaret Basile, Alexis Battle, Joy Boyer, Debra Bradbury, Jason P. Bridge, Amanda Brown, Robin Burges, Christopher Choi, Deborah Colantuoni, Nancy Cox, Emmanouil T. Dermitzakis, Leslie K. Derr, Michael J. Dinsmore, Kenyon Erickson, Johnelle Fleming, Timothée Flutre, Barbara A. Foster, Eric R. Gamazon, Gad Getz, Bryan M. Gillard, Roderic Guigó, Kenneth W. Hambright, Pushpa Hariharan, Rick Hasz, Hae K. Im, Scott Jewell, Ellen Karasik, Manolis Kellis, Pouya Kheradpour, Susan Koester, Daphne Koller, Anuar Konkashbaev, Tuuli Lappalainen, Roger Little, Jun Liu, Edmund Lo, John T. Lonsdale, Chunrong Lu, Daniel G. MacArthur, Harold Magazine, Julian B. Maller, Yvonne Marcus, Deborah C Mash, Mark I. McCarthy, Jeffrey McLean, Bernadette Mestichelli, Mark Miklos, Jean Monlong, Magboeba Mosavel, Michael T. Moser, Sara Mostafavi, Dan L. Nicolae, Jonathan Pritchard, Liqun Qi, Kimberly Ramsey, Manuel A. Rivas, Barnaby E. Robles, Daniel C. Rohrer, Mike Salvatore, Michael Sammeth, John Seleski, Saboor Shad, Laura A. Siminoff, Matthew Stephens, Jeff Struewing, Timothy Sullivan, Susan Sullivan, John Syron, David Tabor, Mehran Taherian, Jorge Tejada, Gary F. Temple, Jeffrey A. Thomas, Alexander W. Thomson, Denee Tidwell, Heather M. Traino, Zhidong Tu, Dana R. Valley, Simona Volpi, Gary D. Walters, Lucas D. Ward, Xiaoquan Wen, Wendy Winckler, Shenpei Wu, Jun Zhu, Assya Abdallah, Anjene Addington, James M. Anderson, Patrick K. Bender, Mark Cosentino, Norma Diaz-Mayoral, Theresa Engel, Fernando Garci, Allen Green, Tiffanie Hammond, Katherine Jaffe, Judy Keen, Mary Kennedy, Peter Kigonya, Brent Lander, Sreenath Nampally, Cathy Ny, James Robb, Vikram Santhanum, Nataliya Sharopova, Shilpi Singh, Conrado Soria, Anne Sturcke, Surendra Sukari, Elizabeth J. Thomson, Magda Tomaszewski, Casandra Trowbridge, Ferdinand Udoye, David Vanscoy, Negin Vatanian, Elizabeth L. Wilder, Penelope Williams

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for extensive genomic analyses. Here we describe how a successful infrastructure for biospecimen procurement was developed and implemented by multiple research partners to support the prospective collection, annotation, and distribution of blood, tissues, and cell lines for the GTEx project. Other research projects can follow this model and form beneficial partnerships with rapid autopsy and organ procurement organizations to collect high quality biospecimens and associated clinical data for genomic studies. Biospecimens, clinical and genomic data, and Standard Operating Procedures guiding biospecimen collection for the GTEx project are available to the research community.

Original languageEnglish (US)
Pages (from-to)311-317
Number of pages7
JournalBiopreservation and Biobanking
Volume13
Issue number5
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Fingerprint

Tissue and Organ Procurement
Genotype
Tissue
Research
Sexual Partners
Medical Genetics
Tissue Distribution
Autopsy
Blood Cells
Gene expression
Organizations
Gene Expression
Cell Line
Blood
Cells

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

Cite this

Carithers, L. J., Ardlie, K., Barcus, M., Branton, P. A., Britton, A., Buia, S. A., ... Williams, P. (2015). A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project. Biopreservation and Biobanking, 13(5), 311-317. https://doi.org/10.1089/bio.2015.0032

A Novel Approach to High-Quality Postmortem Tissue Procurement : The GTEx Project. / Carithers, Latarsha J.; Ardlie, Kristin; Barcus, Mary; Branton, Philip A.; Britton, Angela; Buia, Stephen A.; Compton, Carolyn C.; Deluca, David S.; Peter-Demchok, Joanne; Gelfand, Ellen T.; Guan, Ping; Korzeniewski, Greg E.; Lockhart, Nicole C.; Rabiner, Chana A.; Rao, Abhi K.; Robinson, Karna L.; Roche, Nancy V.; Sawyer, Sherilyn J.; Segrè, Ayellet V.; Shive, Charles E.; Smith, Anna M.; Sobin, Leslie H.; Undale, Anita H.; Valentino, Kimberly M.; Vaught, Jim; Young, Taylor R.; Moore, Helen M.; Barker, Laura; Basile, Margaret; Battle, Alexis; Boyer, Joy; Bradbury, Debra; Bridge, Jason P.; Brown, Amanda; Burges, Robin; Choi, Christopher; Colantuoni, Deborah; Cox, Nancy; Dermitzakis, Emmanouil T.; Derr, Leslie K.; Dinsmore, Michael J.; Erickson, Kenyon; Fleming, Johnelle; Flutre, Timothée; Foster, Barbara A.; Gamazon, Eric R.; Getz, Gad; Gillard, Bryan M.; Guigó, Roderic; Hambright, Kenneth W.; Hariharan, Pushpa; Hasz, Rick; Im, Hae K.; Jewell, Scott; Karasik, Ellen; Kellis, Manolis; Kheradpour, Pouya; Koester, Susan; Koller, Daphne; Konkashbaev, Anuar; Lappalainen, Tuuli; Little, Roger; Liu, Jun; Lo, Edmund; Lonsdale, John T.; Lu, Chunrong; MacArthur, Daniel G.; Magazine, Harold; Maller, Julian B.; Marcus, Yvonne; Mash, Deborah C; McCarthy, Mark I.; McLean, Jeffrey; Mestichelli, Bernadette; Miklos, Mark; Monlong, Jean; Mosavel, Magboeba; Moser, Michael T.; Mostafavi, Sara; Nicolae, Dan L.; Pritchard, Jonathan; Qi, Liqun; Ramsey, Kimberly; Rivas, Manuel A.; Robles, Barnaby E.; Rohrer, Daniel C.; Salvatore, Mike; Sammeth, Michael; Seleski, John; Shad, Saboor; Siminoff, Laura A.; Stephens, Matthew; Struewing, Jeff; Sullivan, Timothy; Sullivan, Susan; Syron, John; Tabor, David; Taherian, Mehran; Tejada, Jorge; Temple, Gary F.; Thomas, Jeffrey A.; Thomson, Alexander W.; Tidwell, Denee; Traino, Heather M.; Tu, Zhidong; Valley, Dana R.; Volpi, Simona; Walters, Gary D.; Ward, Lucas D.; Wen, Xiaoquan; Winckler, Wendy; Wu, Shenpei; Zhu, Jun; Abdallah, Assya; Addington, Anjene; Anderson, James M.; Bender, Patrick K.; Cosentino, Mark; Diaz-Mayoral, Norma; Engel, Theresa; Garci, Fernando; Green, Allen; Hammond, Tiffanie; Jaffe, Katherine; Keen, Judy; Kennedy, Mary; Kigonya, Peter; Lander, Brent; Nampally, Sreenath; Ny, Cathy; Robb, James; Santhanum, Vikram; Sharopova, Nataliya; Singh, Shilpi; Soria, Conrado; Sturcke, Anne; Sukari, Surendra; Thomson, Elizabeth J.; Tomaszewski, Magda; Trowbridge, Casandra; Udoye, Ferdinand; Vanscoy, David; Vatanian, Negin; Wilder, Elizabeth L.; Williams, Penelope.

In: Biopreservation and Biobanking, Vol. 13, No. 5, 01.10.2015, p. 311-317.

Research output: Contribution to journalArticle

Carithers, LJ, Ardlie, K, Barcus, M, Branton, PA, Britton, A, Buia, SA, Compton, CC, Deluca, DS, Peter-Demchok, J, Gelfand, ET, Guan, P, Korzeniewski, GE, Lockhart, NC, Rabiner, CA, Rao, AK, Robinson, KL, Roche, NV, Sawyer, SJ, Segrè, AV, Shive, CE, Smith, AM, Sobin, LH, Undale, AH, Valentino, KM, Vaught, J, Young, TR, Moore, HM, Barker, L, Basile, M, Battle, A, Boyer, J, Bradbury, D, Bridge, JP, Brown, A, Burges, R, Choi, C, Colantuoni, D, Cox, N, Dermitzakis, ET, Derr, LK, Dinsmore, MJ, Erickson, K, Fleming, J, Flutre, T, Foster, BA, Gamazon, ER, Getz, G, Gillard, BM, Guigó, R, Hambright, KW, Hariharan, P, Hasz, R, Im, HK, Jewell, S, Karasik, E, Kellis, M, Kheradpour, P, Koester, S, Koller, D, Konkashbaev, A, Lappalainen, T, Little, R, Liu, J, Lo, E, Lonsdale, JT, Lu, C, MacArthur, DG, Magazine, H, Maller, JB, Marcus, Y, Mash, DC, McCarthy, MI, McLean, J, Mestichelli, B, Miklos, M, Monlong, J, Mosavel, M, Moser, MT, Mostafavi, S, Nicolae, DL, Pritchard, J, Qi, L, Ramsey, K, Rivas, MA, Robles, BE, Rohrer, DC, Salvatore, M, Sammeth, M, Seleski, J, Shad, S, Siminoff, LA, Stephens, M, Struewing, J, Sullivan, T, Sullivan, S, Syron, J, Tabor, D, Taherian, M, Tejada, J, Temple, GF, Thomas, JA, Thomson, AW, Tidwell, D, Traino, HM, Tu, Z, Valley, DR, Volpi, S, Walters, GD, Ward, LD, Wen, X, Winckler, W, Wu, S, Zhu, J, Abdallah, A, Addington, A, Anderson, JM, Bender, PK, Cosentino, M, Diaz-Mayoral, N, Engel, T, Garci, F, Green, A, Hammond, T, Jaffe, K, Keen, J, Kennedy, M, Kigonya, P, Lander, B, Nampally, S, Ny, C, Robb, J, Santhanum, V, Sharopova, N, Singh, S, Soria, C, Sturcke, A, Sukari, S, Thomson, EJ, Tomaszewski, M, Trowbridge, C, Udoye, F, Vanscoy, D, Vatanian, N, Wilder, EL & Williams, P 2015, 'A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project', Biopreservation and Biobanking, vol. 13, no. 5, pp. 311-317. https://doi.org/10.1089/bio.2015.0032
Carithers LJ, Ardlie K, Barcus M, Branton PA, Britton A, Buia SA et al. A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project. Biopreservation and Biobanking. 2015 Oct 1;13(5):311-317. https://doi.org/10.1089/bio.2015.0032
Carithers, Latarsha J. ; Ardlie, Kristin ; Barcus, Mary ; Branton, Philip A. ; Britton, Angela ; Buia, Stephen A. ; Compton, Carolyn C. ; Deluca, David S. ; Peter-Demchok, Joanne ; Gelfand, Ellen T. ; Guan, Ping ; Korzeniewski, Greg E. ; Lockhart, Nicole C. ; Rabiner, Chana A. ; Rao, Abhi K. ; Robinson, Karna L. ; Roche, Nancy V. ; Sawyer, Sherilyn J. ; Segrè, Ayellet V. ; Shive, Charles E. ; Smith, Anna M. ; Sobin, Leslie H. ; Undale, Anita H. ; Valentino, Kimberly M. ; Vaught, Jim ; Young, Taylor R. ; Moore, Helen M. ; Barker, Laura ; Basile, Margaret ; Battle, Alexis ; Boyer, Joy ; Bradbury, Debra ; Bridge, Jason P. ; Brown, Amanda ; Burges, Robin ; Choi, Christopher ; Colantuoni, Deborah ; Cox, Nancy ; Dermitzakis, Emmanouil T. ; Derr, Leslie K. ; Dinsmore, Michael J. ; Erickson, Kenyon ; Fleming, Johnelle ; Flutre, Timothée ; Foster, Barbara A. ; Gamazon, Eric R. ; Getz, Gad ; Gillard, Bryan M. ; Guigó, Roderic ; Hambright, Kenneth W. ; Hariharan, Pushpa ; Hasz, Rick ; Im, Hae K. ; Jewell, Scott ; Karasik, Ellen ; Kellis, Manolis ; Kheradpour, Pouya ; Koester, Susan ; Koller, Daphne ; Konkashbaev, Anuar ; Lappalainen, Tuuli ; Little, Roger ; Liu, Jun ; Lo, Edmund ; Lonsdale, John T. ; Lu, Chunrong ; MacArthur, Daniel G. ; Magazine, Harold ; Maller, Julian B. ; Marcus, Yvonne ; Mash, Deborah C ; McCarthy, Mark I. ; McLean, Jeffrey ; Mestichelli, Bernadette ; Miklos, Mark ; Monlong, Jean ; Mosavel, Magboeba ; Moser, Michael T. ; Mostafavi, Sara ; Nicolae, Dan L. ; Pritchard, Jonathan ; Qi, Liqun ; Ramsey, Kimberly ; Rivas, Manuel A. ; Robles, Barnaby E. ; Rohrer, Daniel C. ; Salvatore, Mike ; Sammeth, Michael ; Seleski, John ; Shad, Saboor ; Siminoff, Laura A. ; Stephens, Matthew ; Struewing, Jeff ; Sullivan, Timothy ; Sullivan, Susan ; Syron, John ; Tabor, David ; Taherian, Mehran ; Tejada, Jorge ; Temple, Gary F. ; Thomas, Jeffrey A. ; Thomson, Alexander W. ; Tidwell, Denee ; Traino, Heather M. ; Tu, Zhidong ; Valley, Dana R. ; Volpi, Simona ; Walters, Gary D. ; Ward, Lucas D. ; Wen, Xiaoquan ; Winckler, Wendy ; Wu, Shenpei ; Zhu, Jun ; Abdallah, Assya ; Addington, Anjene ; Anderson, James M. ; Bender, Patrick K. ; Cosentino, Mark ; Diaz-Mayoral, Norma ; Engel, Theresa ; Garci, Fernando ; Green, Allen ; Hammond, Tiffanie ; Jaffe, Katherine ; Keen, Judy ; Kennedy, Mary ; Kigonya, Peter ; Lander, Brent ; Nampally, Sreenath ; Ny, Cathy ; Robb, James ; Santhanum, Vikram ; Sharopova, Nataliya ; Singh, Shilpi ; Soria, Conrado ; Sturcke, Anne ; Sukari, Surendra ; Thomson, Elizabeth J. ; Tomaszewski, Magda ; Trowbridge, Casandra ; Udoye, Ferdinand ; Vanscoy, David ; Vatanian, Negin ; Wilder, Elizabeth L. ; Williams, Penelope. / A Novel Approach to High-Quality Postmortem Tissue Procurement : The GTEx Project. In: Biopreservation and Biobanking. 2015 ; Vol. 13, No. 5. pp. 311-317.
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TY - JOUR

T1 - A Novel Approach to High-Quality Postmortem Tissue Procurement

T2 - The GTEx Project

AU - Carithers, Latarsha J.

AU - Ardlie, Kristin

AU - Barcus, Mary

AU - Branton, Philip A.

AU - Britton, Angela

AU - Buia, Stephen A.

AU - Compton, Carolyn C.

AU - Deluca, David S.

AU - Peter-Demchok, Joanne

AU - Gelfand, Ellen T.

AU - Guan, Ping

AU - Korzeniewski, Greg E.

AU - Lockhart, Nicole C.

AU - Rabiner, Chana A.

AU - Rao, Abhi K.

AU - Robinson, Karna L.

AU - Roche, Nancy V.

AU - Sawyer, Sherilyn J.

AU - Segrè, Ayellet V.

AU - Shive, Charles E.

AU - Smith, Anna M.

AU - Sobin, Leslie H.

AU - Undale, Anita H.

AU - Valentino, Kimberly M.

AU - Vaught, Jim

AU - Young, Taylor R.

AU - Moore, Helen M.

AU - Barker, Laura

AU - Basile, Margaret

AU - Battle, Alexis

AU - Boyer, Joy

AU - Bradbury, Debra

AU - Bridge, Jason P.

AU - Brown, Amanda

AU - Burges, Robin

AU - Choi, Christopher

AU - Colantuoni, Deborah

AU - Cox, Nancy

AU - Dermitzakis, Emmanouil T.

AU - Derr, Leslie K.

AU - Dinsmore, Michael J.

AU - Erickson, Kenyon

AU - Fleming, Johnelle

AU - Flutre, Timothée

AU - Foster, Barbara A.

AU - Gamazon, Eric R.

AU - Getz, Gad

AU - Gillard, Bryan M.

AU - Guigó, Roderic

AU - Hambright, Kenneth W.

AU - Hariharan, Pushpa

AU - Hasz, Rick

AU - Im, Hae K.

AU - Jewell, Scott

AU - Karasik, Ellen

AU - Kellis, Manolis

AU - Kheradpour, Pouya

AU - Koester, Susan

AU - Koller, Daphne

AU - Konkashbaev, Anuar

AU - Lappalainen, Tuuli

AU - Little, Roger

AU - Liu, Jun

AU - Lo, Edmund

AU - Lonsdale, John T.

AU - Lu, Chunrong

AU - MacArthur, Daniel G.

AU - Magazine, Harold

AU - Maller, Julian B.

AU - Marcus, Yvonne

AU - Mash, Deborah C

AU - McCarthy, Mark I.

AU - McLean, Jeffrey

AU - Mestichelli, Bernadette

AU - Miklos, Mark

AU - Monlong, Jean

AU - Mosavel, Magboeba

AU - Moser, Michael T.

AU - Mostafavi, Sara

AU - Nicolae, Dan L.

AU - Pritchard, Jonathan

AU - Qi, Liqun

AU - Ramsey, Kimberly

AU - Rivas, Manuel A.

AU - Robles, Barnaby E.

AU - Rohrer, Daniel C.

AU - Salvatore, Mike

AU - Sammeth, Michael

AU - Seleski, John

AU - Shad, Saboor

AU - Siminoff, Laura A.

AU - Stephens, Matthew

AU - Struewing, Jeff

AU - Sullivan, Timothy

AU - Sullivan, Susan

AU - Syron, John

AU - Tabor, David

AU - Taherian, Mehran

AU - Tejada, Jorge

AU - Temple, Gary F.

AU - Thomas, Jeffrey A.

AU - Thomson, Alexander W.

AU - Tidwell, Denee

AU - Traino, Heather M.

AU - Tu, Zhidong

AU - Valley, Dana R.

AU - Volpi, Simona

AU - Walters, Gary D.

AU - Ward, Lucas D.

AU - Wen, Xiaoquan

AU - Winckler, Wendy

AU - Wu, Shenpei

AU - Zhu, Jun

AU - Abdallah, Assya

AU - Addington, Anjene

AU - Anderson, James M.

AU - Bender, Patrick K.

AU - Cosentino, Mark

AU - Diaz-Mayoral, Norma

AU - Engel, Theresa

AU - Garci, Fernando

AU - Green, Allen

AU - Hammond, Tiffanie

AU - Jaffe, Katherine

AU - Keen, Judy

AU - Kennedy, Mary

AU - Kigonya, Peter

AU - Lander, Brent

AU - Nampally, Sreenath

AU - Ny, Cathy

AU - Robb, James

AU - Santhanum, Vikram

AU - Sharopova, Nataliya

AU - Singh, Shilpi

AU - Soria, Conrado

AU - Sturcke, Anne

AU - Sukari, Surendra

AU - Thomson, Elizabeth J.

AU - Tomaszewski, Magda

AU - Trowbridge, Casandra

AU - Udoye, Ferdinand

AU - Vanscoy, David

AU - Vatanian, Negin

AU - Wilder, Elizabeth L.

AU - Williams, Penelope

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AB - The Genotype-Tissue Expression (GTEx) project, sponsored by the NIH Common Fund, was established to study the correlation between human genetic variation and tissue-specific gene expression in non-diseased individuals. A significant challenge was the collection of high-quality biospecimens for extensive genomic analyses. Here we describe how a successful infrastructure for biospecimen procurement was developed and implemented by multiple research partners to support the prospective collection, annotation, and distribution of blood, tissues, and cell lines for the GTEx project. Other research projects can follow this model and form beneficial partnerships with rapid autopsy and organ procurement organizations to collect high quality biospecimens and associated clinical data for genomic studies. Biospecimens, clinical and genomic data, and Standard Operating Procedures guiding biospecimen collection for the GTEx project are available to the research community.

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