Abstract
Objective: To report clinical evaluation, flow patency, and histopathological findings of a novel glaucoma drainage implant (GDI) made of poly(styrene-b-isobutylene-b-styrene) (SIBS) in rabbits. Methods: In 16 normal eyes, the proximal end of the SIBS GDI was inserted into the anterior chamber while the distal end was placed in the subconjunctival space. A control group underwent implantation of a similarly designed silicone GDI. Slitlamp follow-up and intraocular pressure measurements were recorded. Flow patency was evaluated by injecting 0.01% fluorescein into the anterior chamber. Immunostaining against collagen IV, macrophages, and α smooth muscle actin was performed. Results: Slitlamp examination suggested adequate biocompatibility. A low and diffuse bleb was observed in the SIBS group. All SIBS tubes were patent 6 months after insertion. Immunostaining demonstrated noncontinuous collagen deposition. No macrophages or myofibroblasts were visible around the SIBS tubes. In contrast, silicone induced collagen deposition and myofibroblast differentiation. Conclusion: This new GDI is clinically biocompatible in the rabbit and maintained 100% patency at 6 months. A remarkable difference was the absence of myofibroblasts in the surrounding tissue in the SIBS group. Clinical Relevance: This novel GDI made of SIBS would prevent the feared complication of hypotony and will decrease the amount of subconjunctival fibrosis.
| Original language | English |
|---|---|
| Pages (from-to) | 1742-1749 |
| Number of pages | 8 |
| Journal | Archives of Ophthalmology |
| Volume | 124 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2006 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
A newly designed glaucoma drainage implant made of poly(styrene-b- isobutylene-b-styrene) : Biocompatibility and function in normal rabbit eyes. / Acosta, Ana C.; Espana, Edgar M.; Yamamoto, Hideo; Davis, Stewart; Pinchuk, Leonard; Weber, Bruce A.; Orozco, Marcia; Dubovy, Sander; Fantes, Francisco; Parel, Jean-Marie A.
In: Archives of Ophthalmology, Vol. 124, No. 12, 01.12.2006, p. 1742-1749.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A newly designed glaucoma drainage implant made of poly(styrene-b- isobutylene-b-styrene)
T2 - Biocompatibility and function in normal rabbit eyes
AU - Acosta, Ana C.
AU - Espana, Edgar M.
AU - Yamamoto, Hideo
AU - Davis, Stewart
AU - Pinchuk, Leonard
AU - Weber, Bruce A.
AU - Orozco, Marcia
AU - Dubovy, Sander
AU - Fantes, Francisco
AU - Parel, Jean-Marie A
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Objective: To report clinical evaluation, flow patency, and histopathological findings of a novel glaucoma drainage implant (GDI) made of poly(styrene-b-isobutylene-b-styrene) (SIBS) in rabbits. Methods: In 16 normal eyes, the proximal end of the SIBS GDI was inserted into the anterior chamber while the distal end was placed in the subconjunctival space. A control group underwent implantation of a similarly designed silicone GDI. Slitlamp follow-up and intraocular pressure measurements were recorded. Flow patency was evaluated by injecting 0.01% fluorescein into the anterior chamber. Immunostaining against collagen IV, macrophages, and α smooth muscle actin was performed. Results: Slitlamp examination suggested adequate biocompatibility. A low and diffuse bleb was observed in the SIBS group. All SIBS tubes were patent 6 months after insertion. Immunostaining demonstrated noncontinuous collagen deposition. No macrophages or myofibroblasts were visible around the SIBS tubes. In contrast, silicone induced collagen deposition and myofibroblast differentiation. Conclusion: This new GDI is clinically biocompatible in the rabbit and maintained 100% patency at 6 months. A remarkable difference was the absence of myofibroblasts in the surrounding tissue in the SIBS group. Clinical Relevance: This novel GDI made of SIBS would prevent the feared complication of hypotony and will decrease the amount of subconjunctival fibrosis.
AB - Objective: To report clinical evaluation, flow patency, and histopathological findings of a novel glaucoma drainage implant (GDI) made of poly(styrene-b-isobutylene-b-styrene) (SIBS) in rabbits. Methods: In 16 normal eyes, the proximal end of the SIBS GDI was inserted into the anterior chamber while the distal end was placed in the subconjunctival space. A control group underwent implantation of a similarly designed silicone GDI. Slitlamp follow-up and intraocular pressure measurements were recorded. Flow patency was evaluated by injecting 0.01% fluorescein into the anterior chamber. Immunostaining against collagen IV, macrophages, and α smooth muscle actin was performed. Results: Slitlamp examination suggested adequate biocompatibility. A low and diffuse bleb was observed in the SIBS group. All SIBS tubes were patent 6 months after insertion. Immunostaining demonstrated noncontinuous collagen deposition. No macrophages or myofibroblasts were visible around the SIBS tubes. In contrast, silicone induced collagen deposition and myofibroblast differentiation. Conclusion: This new GDI is clinically biocompatible in the rabbit and maintained 100% patency at 6 months. A remarkable difference was the absence of myofibroblasts in the surrounding tissue in the SIBS group. Clinical Relevance: This novel GDI made of SIBS would prevent the feared complication of hypotony and will decrease the amount of subconjunctival fibrosis.
UR - http://www.scopus.com/inward/record.url?scp=33845477018&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845477018&partnerID=8YFLogxK
U2 - 10.1001/archopht.124.12.1742
DO - 10.1001/archopht.124.12.1742
M3 - Article
C2 - 17159034
AN - SCOPUS:33845477018
VL - 124
SP - 1742
EP - 1749
JO - JAMA Ophthalmology
JF - JAMA Ophthalmology
SN - 2168-6165
IS - 12
ER -