A newly designed glaucoma drainage implant made of poly(styrene-b- isobutylene-b-styrene): Biocompatibility and function in normal rabbit eyes

Ana C. Acosta, Edgar M. Espana, Hideo Yamamoto, Stewart Davis, Leonard Pinchuk, Bruce A. Weber, Marcia Orozco, Sander Dubovy, Francisco Fantes, Jean-Marie A Parel

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective: To report clinical evaluation, flow patency, and histopathological findings of a novel glaucoma drainage implant (GDI) made of poly(styrene-b-isobutylene-b-styrene) (SIBS) in rabbits. Methods: In 16 normal eyes, the proximal end of the SIBS GDI was inserted into the anterior chamber while the distal end was placed in the subconjunctival space. A control group underwent implantation of a similarly designed silicone GDI. Slitlamp follow-up and intraocular pressure measurements were recorded. Flow patency was evaluated by injecting 0.01% fluorescein into the anterior chamber. Immunostaining against collagen IV, macrophages, and α smooth muscle actin was performed. Results: Slitlamp examination suggested adequate biocompatibility. A low and diffuse bleb was observed in the SIBS group. All SIBS tubes were patent 6 months after insertion. Immunostaining demonstrated noncontinuous collagen deposition. No macrophages or myofibroblasts were visible around the SIBS tubes. In contrast, silicone induced collagen deposition and myofibroblast differentiation. Conclusion: This new GDI is clinically biocompatible in the rabbit and maintained 100% patency at 6 months. A remarkable difference was the absence of myofibroblasts in the surrounding tissue in the SIBS group. Clinical Relevance: This novel GDI made of SIBS would prevent the feared complication of hypotony and will decrease the amount of subconjunctival fibrosis.

Original languageEnglish
Pages (from-to)1742-1749
Number of pages8
JournalArchives of Ophthalmology
Volume124
Issue number12
DOIs
StatePublished - Dec 1 2006

Fingerprint

Glaucoma Drainage Implants
Styrene
Rabbits
Myofibroblasts
Collagen
Anterior Chamber
Silicones
poly(styrene-b-isobutylene-b-styrene)
Macrophages
Blister
Fluorescein
Intraocular Pressure

ASJC Scopus subject areas

  • Ophthalmology

Cite this

A newly designed glaucoma drainage implant made of poly(styrene-b- isobutylene-b-styrene) : Biocompatibility and function in normal rabbit eyes. / Acosta, Ana C.; Espana, Edgar M.; Yamamoto, Hideo; Davis, Stewart; Pinchuk, Leonard; Weber, Bruce A.; Orozco, Marcia; Dubovy, Sander; Fantes, Francisco; Parel, Jean-Marie A.

In: Archives of Ophthalmology, Vol. 124, No. 12, 01.12.2006, p. 1742-1749.

Research output: Contribution to journalArticle

Acosta, Ana C. ; Espana, Edgar M. ; Yamamoto, Hideo ; Davis, Stewart ; Pinchuk, Leonard ; Weber, Bruce A. ; Orozco, Marcia ; Dubovy, Sander ; Fantes, Francisco ; Parel, Jean-Marie A. / A newly designed glaucoma drainage implant made of poly(styrene-b- isobutylene-b-styrene) : Biocompatibility and function in normal rabbit eyes. In: Archives of Ophthalmology. 2006 ; Vol. 124, No. 12. pp. 1742-1749.
@article{0f27ae33f3894397a885ed291f139d0d,
title = "A newly designed glaucoma drainage implant made of poly(styrene-b- isobutylene-b-styrene): Biocompatibility and function in normal rabbit eyes",
abstract = "Objective: To report clinical evaluation, flow patency, and histopathological findings of a novel glaucoma drainage implant (GDI) made of poly(styrene-b-isobutylene-b-styrene) (SIBS) in rabbits. Methods: In 16 normal eyes, the proximal end of the SIBS GDI was inserted into the anterior chamber while the distal end was placed in the subconjunctival space. A control group underwent implantation of a similarly designed silicone GDI. Slitlamp follow-up and intraocular pressure measurements were recorded. Flow patency was evaluated by injecting 0.01{\%} fluorescein into the anterior chamber. Immunostaining against collagen IV, macrophages, and α smooth muscle actin was performed. Results: Slitlamp examination suggested adequate biocompatibility. A low and diffuse bleb was observed in the SIBS group. All SIBS tubes were patent 6 months after insertion. Immunostaining demonstrated noncontinuous collagen deposition. No macrophages or myofibroblasts were visible around the SIBS tubes. In contrast, silicone induced collagen deposition and myofibroblast differentiation. Conclusion: This new GDI is clinically biocompatible in the rabbit and maintained 100{\%} patency at 6 months. A remarkable difference was the absence of myofibroblasts in the surrounding tissue in the SIBS group. Clinical Relevance: This novel GDI made of SIBS would prevent the feared complication of hypotony and will decrease the amount of subconjunctival fibrosis.",
author = "Acosta, {Ana C.} and Espana, {Edgar M.} and Hideo Yamamoto and Stewart Davis and Leonard Pinchuk and Weber, {Bruce A.} and Marcia Orozco and Sander Dubovy and Francisco Fantes and Parel, {Jean-Marie A}",
year = "2006",
month = "12",
day = "1",
doi = "10.1001/archopht.124.12.1742",
language = "English",
volume = "124",
pages = "1742--1749",
journal = "JAMA Ophthalmology",
issn = "2168-6165",
publisher = "American Medical Association",
number = "12",

}

TY - JOUR

T1 - A newly designed glaucoma drainage implant made of poly(styrene-b- isobutylene-b-styrene)

T2 - Biocompatibility and function in normal rabbit eyes

AU - Acosta, Ana C.

AU - Espana, Edgar M.

AU - Yamamoto, Hideo

AU - Davis, Stewart

AU - Pinchuk, Leonard

AU - Weber, Bruce A.

AU - Orozco, Marcia

AU - Dubovy, Sander

AU - Fantes, Francisco

AU - Parel, Jean-Marie A

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Objective: To report clinical evaluation, flow patency, and histopathological findings of a novel glaucoma drainage implant (GDI) made of poly(styrene-b-isobutylene-b-styrene) (SIBS) in rabbits. Methods: In 16 normal eyes, the proximal end of the SIBS GDI was inserted into the anterior chamber while the distal end was placed in the subconjunctival space. A control group underwent implantation of a similarly designed silicone GDI. Slitlamp follow-up and intraocular pressure measurements were recorded. Flow patency was evaluated by injecting 0.01% fluorescein into the anterior chamber. Immunostaining against collagen IV, macrophages, and α smooth muscle actin was performed. Results: Slitlamp examination suggested adequate biocompatibility. A low and diffuse bleb was observed in the SIBS group. All SIBS tubes were patent 6 months after insertion. Immunostaining demonstrated noncontinuous collagen deposition. No macrophages or myofibroblasts were visible around the SIBS tubes. In contrast, silicone induced collagen deposition and myofibroblast differentiation. Conclusion: This new GDI is clinically biocompatible in the rabbit and maintained 100% patency at 6 months. A remarkable difference was the absence of myofibroblasts in the surrounding tissue in the SIBS group. Clinical Relevance: This novel GDI made of SIBS would prevent the feared complication of hypotony and will decrease the amount of subconjunctival fibrosis.

AB - Objective: To report clinical evaluation, flow patency, and histopathological findings of a novel glaucoma drainage implant (GDI) made of poly(styrene-b-isobutylene-b-styrene) (SIBS) in rabbits. Methods: In 16 normal eyes, the proximal end of the SIBS GDI was inserted into the anterior chamber while the distal end was placed in the subconjunctival space. A control group underwent implantation of a similarly designed silicone GDI. Slitlamp follow-up and intraocular pressure measurements were recorded. Flow patency was evaluated by injecting 0.01% fluorescein into the anterior chamber. Immunostaining against collagen IV, macrophages, and α smooth muscle actin was performed. Results: Slitlamp examination suggested adequate biocompatibility. A low and diffuse bleb was observed in the SIBS group. All SIBS tubes were patent 6 months after insertion. Immunostaining demonstrated noncontinuous collagen deposition. No macrophages or myofibroblasts were visible around the SIBS tubes. In contrast, silicone induced collagen deposition and myofibroblast differentiation. Conclusion: This new GDI is clinically biocompatible in the rabbit and maintained 100% patency at 6 months. A remarkable difference was the absence of myofibroblasts in the surrounding tissue in the SIBS group. Clinical Relevance: This novel GDI made of SIBS would prevent the feared complication of hypotony and will decrease the amount of subconjunctival fibrosis.

UR - http://www.scopus.com/inward/record.url?scp=33845477018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33845477018&partnerID=8YFLogxK

U2 - 10.1001/archopht.124.12.1742

DO - 10.1001/archopht.124.12.1742

M3 - Article

C2 - 17159034

AN - SCOPUS:33845477018

VL - 124

SP - 1742

EP - 1749

JO - JAMA Ophthalmology

JF - JAMA Ophthalmology

SN - 2168-6165

IS - 12

ER -