A newly designed glaucoma drainage implant made of poly(styrene-b- isobutylene-b-styrene): Biocompatibility and function in normal rabbit eyes

Ana C. Acosta, Edgar M. Espana, Hideo Yamamoto, Stewart Davis, Leonard Pinchuk, Bruce A. Weber, Marcia Orozco, Sander Dubovy, Francisco Fantes, Jean Marie Parel

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Objective: To report clinical evaluation, flow patency, and histopathological findings of a novel glaucoma drainage implant (GDI) made of poly(styrene-b-isobutylene-b-styrene) (SIBS) in rabbits. Methods: In 16 normal eyes, the proximal end of the SIBS GDI was inserted into the anterior chamber while the distal end was placed in the subconjunctival space. A control group underwent implantation of a similarly designed silicone GDI. Slitlamp follow-up and intraocular pressure measurements were recorded. Flow patency was evaluated by injecting 0.01% fluorescein into the anterior chamber. Immunostaining against collagen IV, macrophages, and α smooth muscle actin was performed. Results: Slitlamp examination suggested adequate biocompatibility. A low and diffuse bleb was observed in the SIBS group. All SIBS tubes were patent 6 months after insertion. Immunostaining demonstrated noncontinuous collagen deposition. No macrophages or myofibroblasts were visible around the SIBS tubes. In contrast, silicone induced collagen deposition and myofibroblast differentiation. Conclusion: This new GDI is clinically biocompatible in the rabbit and maintained 100% patency at 6 months. A remarkable difference was the absence of myofibroblasts in the surrounding tissue in the SIBS group. Clinical Relevance: This novel GDI made of SIBS would prevent the feared complication of hypotony and will decrease the amount of subconjunctival fibrosis.

Original languageEnglish (US)
Pages (from-to)1742-1749
Number of pages8
JournalArchives of ophthalmology
Volume124
Issue number12
DOIs
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'A newly designed glaucoma drainage implant made of poly(styrene-b- isobutylene-b-styrene): Biocompatibility and function in normal rabbit eyes'. Together they form a unique fingerprint.

  • Cite this