A new type D retrovirus isolated from macaques with an immunodeficiency syndrome

Muthiah D. Daniel; Norval W. King; Norman L. Letvin; Ronald D. Hunt; Prabhat K. Sehgal; Ronald C. Desrosiers

doi:10.1126/science.6695172

A new type D retrovirus isolated from macaques with an immunodeficiency syndrome

Muthiah D. Daniel, Norval W. King, Norman L. Letvin, Ronald D. Hunt, Prabhat K. Sehgal, Ronald C. Desrosiers

Research output: Contribution to journal › Article › peer-review

152 Scopus citations

Abstract

Macaque monkeys with the recently described acquired immunodeficiency syndrome show a marked defect in T-lymphocyte function and die with opportunistic infections and lymphoproliferative abnormalities. In the study described here a new type D retrovirus was isolatedfrom two Macaca cyclopis with this syndrome. This virus is related to, but distinct from, Mason-Pfizer monkey virus, a type D retrovirus previously isolated from a mammary tumor of a rhesus monkey (Macaca mulatta).

Original language	English (US)
Pages (from-to)	602-605
Number of pages	4
Journal	Science
Volume	223
Issue number	4636
DOIs	https://doi.org/10.1126/science.6695172
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

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title = "A new type D retrovirus isolated from macaques with an immunodeficiency syndrome",

abstract = "Macaque monkeys with the recently described acquired immunodeficiency syndrome show a marked defect in T-lymphocyte function and die with opportunistic infections and lymphoproliferative abnormalities. In the study described here a new type D retrovirus was isolatedfrom two Macaca cyclopis with this syndrome. This virus is related to, but distinct from, Mason-Pfizer monkey virus, a type D retrovirus previously isolated from a mammary tumor of a rhesus monkey (Macaca mulatta).",

author = "Daniel, {Muthiah D.} and King, {Norval W.} and Letvin, {Norman L.} and Hunt, {Ronald D.} and Sehgal, {Prabhat K.} and Desrosiers, {Ronald C.}",

year = "1984",

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AU - Daniel, Muthiah D.

AU - King, Norval W.

AU - Letvin, Norman L.

AU - Hunt, Ronald D.

AU - Sehgal, Prabhat K.

AU - Desrosiers, Ronald C.

PY - 1984

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N2 - Macaque monkeys with the recently described acquired immunodeficiency syndrome show a marked defect in T-lymphocyte function and die with opportunistic infections and lymphoproliferative abnormalities. In the study described here a new type D retrovirus was isolatedfrom two Macaca cyclopis with this syndrome. This virus is related to, but distinct from, Mason-Pfizer monkey virus, a type D retrovirus previously isolated from a mammary tumor of a rhesus monkey (Macaca mulatta).

AB - Macaque monkeys with the recently described acquired immunodeficiency syndrome show a marked defect in T-lymphocyte function and die with opportunistic infections and lymphoproliferative abnormalities. In the study described here a new type D retrovirus was isolatedfrom two Macaca cyclopis with this syndrome. This virus is related to, but distinct from, Mason-Pfizer monkey virus, a type D retrovirus previously isolated from a mammary tumor of a rhesus monkey (Macaca mulatta).

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