A new process for cell encapsulation: Thermal gelation and chemical cross-Linking in 'tandem'

F. Cellesi, N. Tirelli, J. A. Hubbell

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The use of the tandem process, which include the thermal gelation and chemical crosslinking, for cell encapsulation was discussed. In the cross-linking reaction, telechelic linear or star poly(propylene glycol)-bl-poly(ethylene glycol)-bl-(propylene glycol) copolymers bearing reactive end groups were used. The optimization of the macromolecular architecture and functionality of the polymer precursors for allowing the use of tandem process in encapsulation devices designed for calcium alginate was also discussed. The results show that the application of the tandem gelation in single or double nozzle encapsulators produces monodisperse beads or capsules, which are used for cell encapsulation.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
StatePublished - Dec 1 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Cellesi, F., Tirelli, N., & Hubbell, J. A. (2004). A new process for cell encapsulation: Thermal gelation and chemical cross-Linking in 'tandem'. In Transactions - 7th World Biomaterials Congress