Abstract
An algorithm on the fundamental advantages of LC-MS involving high-resolution separation and archiving of data was discussed. A Peak-picking software based on the algorithm was developed. The software was successfully tested in the analysis of a tryptic digest of a mixture of 9 proteins. The advantage of this correlation function approach lie on it's ability to calculate more precisely peak centroids and quantitate the amount of corresponding peptide by using a priori information about the shapes of chromatographic and MS peaks. The algorithm can be used for LC LC(CE)-MALDI-MS in addition to LC (CE)-ESI-MS data.
| Original language | English |
|---|---|
| Title of host publication | Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics |
| Pages | 757-758 |
| Number of pages | 2 |
| State | Published - Dec 1 2002 |
| Event | Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States Duration: Jun 2 2002 → Jun 6 2002 |
Other
| Other | Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics |
|---|---|
| Country | United States |
| City | Orlando, FL |
| Period | 6/2/02 → 6/6/02 |
ASJC Scopus subject areas
- Spectroscopy
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Cite this
Andreev, V. P., Rejtar, T., Chen, H., Moskovets, E. V., & Karger, B. L. (2002). A new peak picking algorithm for LC-MS: Analysis of protein mixture digests. In Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics (pp. 757-758)