A new model system for studying the phosphatidylinositol cycle

Marie E. Monaco, Marc E. Lippman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


An early manifestation of the response of WRK-1 rat mammary tumor cells to vasopressin is an increase in incorporation of (32P)Pi into phospholipids. Incorporation into all classes of phospholipids is stimulated; however, incorporation into phosphatidylinositol (Pl) is increased to the greatest degree (3- to 10-fold as compared with 1.3- to 2-fold for the other phospholipids). Furthermore, increased incorporation into Pl is accompanied by an increased rate of Pl turnover; turnover rates of the other phospholipids are unaffected by vasopressin.

Original languageEnglish (US)
Pages (from-to)148-153
Number of pages6
JournalJournal of Cellular Physiology
Issue number1
StatePublished - Jul 1982

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology


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