A new method to determine the electrical transfer function of the human thorax

Jeffrey Goldberger, Haris Subacius, Indranil Sen-Gupta, David Johnson, Alan H. Kadish, Jason Ng

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Traditional analyses have assumed that cardiac electrical activity is reflected on the surface ECG without distortion as the signal passes through the body tissues. This study aims to explore the frequency dependence of thoracic attenuation of surface-recorded intracardiac electrical activity. Twenty patients (14 men, 55 ± 15 yr of age) undergoing electrophysiological study were enrolled. Rectangular unipolar stimuli were applied from a catheter positioned in the right ventricular apical area and another in the posteroseptal area without contact with the myocardium. An orthogonal Frank-lead surface ECG and a unipolar intracardiac electrogram near the pacing site were recorded. Frequency domain characteristics of the signal-averaged pacing impulses were analyzed. Linear regression analysis showed significant frequency-dependent attenuation in the magnitude transfer functions (R2 = 0.84-0.89, P < 0.0001) and good linear fit for the phase transfer characteristics (R 2 = 0.98 -1.0, P < 0.0001). Age, physical dimension, and respiratory characteristics had significant effects on the magnitude and phase characteristics of the transfer functions. Application of models of the low- and high-slope transfer functions to signal-averaged ECGs from 33 subjects showed differences in the attenuation of P and T waves relative to the QRS.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume293
Issue number6
DOIs
StatePublished - Dec 1 2007
Externally publishedYes

Fingerprint

Electrocardiography
Thorax
Cardiac Electrophysiologic Techniques
Linear Models
Myocardium
Catheters
Regression Analysis
Lead

Keywords

  • Electrocardiography
  • Fourier analysis
  • Pacing

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

A new method to determine the electrical transfer function of the human thorax. / Goldberger, Jeffrey; Subacius, Haris; Sen-Gupta, Indranil; Johnson, David; Kadish, Alan H.; Ng, Jason.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 293, No. 6, 01.12.2007.

Research output: Contribution to journalArticle

Goldberger, Jeffrey ; Subacius, Haris ; Sen-Gupta, Indranil ; Johnson, David ; Kadish, Alan H. ; Ng, Jason. / A new method to determine the electrical transfer function of the human thorax. In: American Journal of Physiology - Heart and Circulatory Physiology. 2007 ; Vol. 293, No. 6.
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