A new human slow skeletal troponin T (TnTs) mRNA isoform derived from alternative splicing of a single gene

F. Samson, L. Mesnard, M. Mihovilovic, T. G. Potter, J. J. Mercadier, A. D. Roses, John Gilbert

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A human muscle cDNA library was screened for slow skeletal troponin T (TnTs). Sequence analysis revealed that one of the selected clones had a cDNA coding sequence different from the two previously described. RNase protection assays confirmed the expression of this new isoform in adult skeletal muscle. In addition, results of the RNase protection assays strongly suggested the expression of a fourth isoform. These isoforms for human slow TnT most likely result from combinatorial alternative splicing of a single gene.

Original languageEnglish
Pages (from-to)841-847
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume199
Issue number2
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

RNA Isoforms
Troponin T
Alternative Splicing
Protein Isoforms
Genes
Ribonucleases
Muscle
Assays
Gene Library
Sequence Analysis
Skeletal Muscle
Complementary DNA
Clone Cells
Muscles

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Samson, F., Mesnard, L., Mihovilovic, M., Potter, T. G., Mercadier, J. J., Roses, A. D., & Gilbert, J. (1994). A new human slow skeletal troponin T (TnTs) mRNA isoform derived from alternative splicing of a single gene. Biochemical and Biophysical Research Communications, 199(2), 841-847. https://doi.org/10.1006/bbrc.1994.1305

A new human slow skeletal troponin T (TnTs) mRNA isoform derived from alternative splicing of a single gene. / Samson, F.; Mesnard, L.; Mihovilovic, M.; Potter, T. G.; Mercadier, J. J.; Roses, A. D.; Gilbert, John.

In: Biochemical and Biophysical Research Communications, Vol. 199, No. 2, 01.01.1994, p. 841-847.

Research output: Contribution to journalArticle

Samson, F, Mesnard, L, Mihovilovic, M, Potter, TG, Mercadier, JJ, Roses, AD & Gilbert, J 1994, 'A new human slow skeletal troponin T (TnTs) mRNA isoform derived from alternative splicing of a single gene', Biochemical and Biophysical Research Communications, vol. 199, no. 2, pp. 841-847. https://doi.org/10.1006/bbrc.1994.1305
Samson, F. ; Mesnard, L. ; Mihovilovic, M. ; Potter, T. G. ; Mercadier, J. J. ; Roses, A. D. ; Gilbert, John. / A new human slow skeletal troponin T (TnTs) mRNA isoform derived from alternative splicing of a single gene. In: Biochemical and Biophysical Research Communications. 1994 ; Vol. 199, No. 2. pp. 841-847.
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