A new human slow skeletal troponin T (TnTs) mrna isoform derived from alternative splicing of a single gene

Françoise Samson, Laurence Mesnard, Mirta Mihovilovic, Tamara G. Potter, Jean Jacques Mercadier, Allen D. Roses, John R. Gilbert

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

A human muscle cDNA library was screened for slow skeletal troponin T (TnTs). Sequence analysis revealed that one of the selected clones had a cDNA coding sequence different from the two previously described. RNase protection assays confirmed the expression of this new isoform in adult skeletal muscle. In addition, results of the RNase protection assays strongly suggested the expression of a fourth isoform. These isoforms for human slow TnT most likely result from combinatorial alternative splicing of a single gene.

Original languageEnglish (US)
Pages (from-to)841-847
Number of pages7
JournalBiochemical and biophysical research communications
Volume199
Issue number2
DOIs
StatePublished - Mar 15 1994

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'A new human slow skeletal troponin T (TnTs) mrna isoform derived from alternative splicing of a single gene'. Together they form a unique fingerprint.

  • Cite this

    Samson, F., Mesnard, L., Mihovilovic, M., Potter, T. G., Mercadier, J. J., Roses, A. D., & Gilbert, J. R. (1994). A new human slow skeletal troponin T (TnTs) mrna isoform derived from alternative splicing of a single gene. Biochemical and biophysical research communications, 199(2), 841-847. https://doi.org/10.1006/bbrc.1994.1305