A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3

D. V. Ivanov; T. V. Tyazhelova; L. Lemonnier; N. Kononenko; A. A. Pestova; E. A. Nikitin; N. Prevarskaya; R. Skryma; Y. V. Panchin; N. K. Yankovsky; A. V. Baranova

doi:10.1016/S0014-5793(03)00211-4

A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3

D. V. Ivanov, T. V. Tyazhelova, L. Lemonnier, N. Kononenko, A. A. Pestova, E. A. Nikitin, N. Prevarskaya, R. Skryma, Y. V. Panchin, N. K. Yankovsky, A. V. Baranova

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This gene includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues and in some tumor cell lines. Protein KCNRG has high homology to tetramerization domain of voltage-gated K⁺ channels. Using the patch-clamp technique we determined that KCNRG suppresses K⁺ channel activity in human prostate cell line LNCaP. It is known that selective blockers of K⁺ channels suppress lymphocyte and LNCaP cell line proliferation. We suggest that KCNRG is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene.

Original language	English (US)
Pages (from-to)	156-160
Number of pages	5
Journal	FEBS letters
Volume	539
Issue number	1-3
DOIs	https://doi.org/10.1016/S0014-5793(03)00211-4
State	Published - Mar 27 2003
Externally published	Yes

Keywords

13q14.3
B-cell chronic lymphocytic leukemia
K channel regulating protein
Prostate cancer
Tumor suppressor gene

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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Ivanov, D. V., Tyazhelova, T. V., Lemonnier, L., Kononenko, N., Pestova, A. A., Nikitin, E. A., Prevarskaya, N., Skryma, R., Panchin, Y. V., Yankovsky, N. K., & Baranova, A. V. (2003). A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3. FEBS letters, 539(1-3), 156-160. https://doi.org/10.1016/S0014-5793(03)00211-4

A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3. / Ivanov, D. V.; Tyazhelova, T. V.; Lemonnier, L.; Kononenko, N.; Pestova, A. A.; Nikitin, E. A.; Prevarskaya, N.; Skryma, R.; Panchin, Y. V.; Yankovsky, N. K.; Baranova, A. V.

In: FEBS letters, Vol. 539, No. 1-3, 27.03.2003, p. 156-160.

Research output: Contribution to journal › Article › peer-review

Ivanov, DV, Tyazhelova, TV, Lemonnier, L, Kononenko, N, Pestova, AA, Nikitin, EA, Prevarskaya, N, Skryma, R, Panchin, YV, Yankovsky, NK & Baranova, AV 2003, 'A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3', FEBS letters, vol. 539, no. 1-3, pp. 156-160. https://doi.org/10.1016/S0014-5793(03)00211-4

Ivanov, D. V. ; Tyazhelova, T. V. ; Lemonnier, L. ; Kononenko, N. ; Pestova, A. A. ; Nikitin, E. A. ; Prevarskaya, N. ; Skryma, R. ; Panchin, Y. V. ; Yankovsky, N. K. ; Baranova, A. V. / A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3. In: FEBS letters. 2003 ; Vol. 539, No. 1-3. pp. 156-160.

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title = "A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3",

abstract = "We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This gene includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues and in some tumor cell lines. Protein KCNRG has high homology to tetramerization domain of voltage-gated K+ channels. Using the patch-clamp technique we determined that KCNRG suppresses K+ channel activity in human prostate cell line LNCaP. It is known that selective blockers of K+ channels suppress lymphocyte and LNCaP cell line proliferation. We suggest that KCNRG is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene.",

keywords = "13q14.3, B-cell chronic lymphocytic leukemia, K channel regulating protein, Prostate cancer, Tumor suppressor gene",

author = "Ivanov, {D. V.} and Tyazhelova, {T. V.} and L. Lemonnier and N. Kononenko and Pestova, {A. A.} and Nikitin, {E. A.} and N. Prevarskaya and R. Skryma and Panchin, {Y. V.} and Yankovsky, {N. K.} and Baranova, {A. V.}",

note = "Funding Information: This research was supported by “Cancer Genomics and Development of Diagnostic Tools and Therapies” grant (Commonwealth Technology Research Fund) and by Russian Human Genome Project, Russian Foundation for Basic Research (grants 02-04-48849-a, 02-04-48775-a and 02-04-48352-a).",

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T1 - A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3

AU - Ivanov, D. V.

AU - Tyazhelova, T. V.

AU - Lemonnier, L.

AU - Kononenko, N.

AU - Pestova, A. A.

AU - Nikitin, E. A.

AU - Prevarskaya, N.

AU - Skryma, R.

AU - Panchin, Y. V.

AU - Yankovsky, N. K.

AU - Baranova, A. V.

N1 - Funding Information: This research was supported by “Cancer Genomics and Development of Diagnostic Tools and Therapies” grant (Commonwealth Technology Research Fund) and by Russian Human Genome Project, Russian Foundation for Basic Research (grants 02-04-48849-a, 02-04-48775-a and 02-04-48352-a).

PY - 2003/3/27

Y1 - 2003/3/27

N2 - We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This gene includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues and in some tumor cell lines. Protein KCNRG has high homology to tetramerization domain of voltage-gated K+ channels. Using the patch-clamp technique we determined that KCNRG suppresses K+ channel activity in human prostate cell line LNCaP. It is known that selective blockers of K+ channels suppress lymphocyte and LNCaP cell line proliferation. We suggest that KCNRG is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene.

AB - We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This gene includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues and in some tumor cell lines. Protein KCNRG has high homology to tetramerization domain of voltage-gated K+ channels. Using the patch-clamp technique we determined that KCNRG suppresses K+ channel activity in human prostate cell line LNCaP. It is known that selective blockers of K+ channels suppress lymphocyte and LNCaP cell line proliferation. We suggest that KCNRG is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene.

KW - 13q14.3

KW - B-cell chronic lymphocytic leukemia

KW - K channel regulating protein

KW - Prostate cancer

KW - Tumor suppressor gene

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