Abstract
We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This gene includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues and in some tumor cell lines. Protein KCNRG has high homology to tetramerization domain of voltage-gated K+ channels. Using the patch-clamp technique we determined that KCNRG suppresses K+ channel activity in human prostate cell line LNCaP. It is known that selective blockers of K+ channels suppress lymphocyte and LNCaP cell line proliferation. We suggest that KCNRG is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene.
| Original language | English |
|---|---|
| Pages (from-to) | 156-160 |
| Number of pages | 5 |
| Journal | FEBS Letters |
| Volume | 539 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Mar 27 2003 |
| Externally published | Yes |
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Keywords
- 13q14.3
- B-cell chronic lymphocytic leukemia
- K channel regulating protein
- Prostate cancer
- Tumor suppressor gene
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3. / Ivanov, Dmitry V; Tyazhelova, T. V.; Lemonnier, L.; Kononenko, N.; Pestova, A. A.; Nikitin, E. A.; Prevarskaya, N.; Skryma, R.; Panchin, Y. V.; Yankovsky, N. K.; Baranova, A. V.
In: FEBS Letters, Vol. 539, No. 1-3, 27.03.2003, p. 156-160.Research output: Contribution to journal › Article
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TY - JOUR
T1 - A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3
AU - Ivanov, Dmitry V
AU - Tyazhelova, T. V.
AU - Lemonnier, L.
AU - Kononenko, N.
AU - Pestova, A. A.
AU - Nikitin, E. A.
AU - Prevarskaya, N.
AU - Skryma, R.
AU - Panchin, Y. V.
AU - Yankovsky, N. K.
AU - Baranova, A. V.
PY - 2003/3/27
Y1 - 2003/3/27
N2 - We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This gene includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues and in some tumor cell lines. Protein KCNRG has high homology to tetramerization domain of voltage-gated K+ channels. Using the patch-clamp technique we determined that KCNRG suppresses K+ channel activity in human prostate cell line LNCaP. It is known that selective blockers of K+ channels suppress lymphocyte and LNCaP cell line proliferation. We suggest that KCNRG is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene.
AB - We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This gene includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues and in some tumor cell lines. Protein KCNRG has high homology to tetramerization domain of voltage-gated K+ channels. Using the patch-clamp technique we determined that KCNRG suppresses K+ channel activity in human prostate cell line LNCaP. It is known that selective blockers of K+ channels suppress lymphocyte and LNCaP cell line proliferation. We suggest that KCNRG is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene.
KW - 13q14.3
KW - B-cell chronic lymphocytic leukemia
KW - K channel regulating protein
KW - Prostate cancer
KW - Tumor suppressor gene
UR - http://www.scopus.com/inward/record.url?scp=0037468613&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037468613&partnerID=8YFLogxK
U2 - 10.1016/S0014-5793(03)00211-4
DO - 10.1016/S0014-5793(03)00211-4
M3 - Article
C2 - 12650944
AN - SCOPUS:0037468613
VL - 539
SP - 156
EP - 160
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1-3
ER -