A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3

D. V. Ivanov, T. V. Tyazhelova, L. Lemonnier, N. Kononenko, A. A. Pestova, E. A. Nikitin, N. Prevarskaya, R. Skryma, Y. V. Panchin, N. K. Yankovsky, A. V. Baranova

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This gene includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues and in some tumor cell lines. Protein KCNRG has high homology to tetramerization domain of voltage-gated K+ channels. Using the patch-clamp technique we determined that KCNRG suppresses K+ channel activity in human prostate cell line LNCaP. It is known that selective blockers of K+ channels suppress lymphocyte and LNCaP cell line proliferation. We suggest that KCNRG is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene.

Original languageEnglish (US)
Pages (from-to)156-160
Number of pages5
JournalFEBS letters
Volume539
Issue number1-3
DOIs
StatePublished - Mar 27 2003
Externally publishedYes

Keywords

  • 13q14.3
  • B-cell chronic lymphocytic leukemia
  • K channel regulating protein
  • Prostate cancer
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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    Ivanov, D. V., Tyazhelova, T. V., Lemonnier, L., Kononenko, N., Pestova, A. A., Nikitin, E. A., Prevarskaya, N., Skryma, R., Panchin, Y. V., Yankovsky, N. K., & Baranova, A. V. (2003). A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3. FEBS letters, 539(1-3), 156-160. https://doi.org/10.1016/S0014-5793(03)00211-4