Abstract
Equation presented A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3277-3280 |
| Number of pages | 4 |
| Journal | Organic letters |
| Volume | 3 |
| Issue number | 21 |
| DOIs | |
| State | Published - Oct 18 2001 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Zheng, Y., Huo, Q., Kele, P., Andreopoulos, F. M., Pham, S. M., & Leblanc, R. M. (2001). A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK). Organic letters, 3(21), 3277-3280. https://doi.org/10.1021/ol0101638