A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK)

Yujun Zheng, Qun Huo, Peter Kele, Fotios M Andreopoulos, Si M. Pham, Roger Leblanc

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Equation presented A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.

Original languageEnglish
Pages (from-to)3277-3280
Number of pages4
JournalOrganic Letters
Volume3
Issue number21
DOIs
StatePublished - Oct 18 2001

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glycyl-histidyl-lysine
Solid-Phase Synthesis Techniques
lysine
peptides
Copper
Fluorescence
Ions
Synthetic Chemistry Techniques
copper
fluorescence
Peptides
spectral emission
solid phases
Quenching
ions
quenching
Molecules
synthesis
molecules

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK). / Zheng, Yujun; Huo, Qun; Kele, Peter; Andreopoulos, Fotios M; Pham, Si M.; Leblanc, Roger.

In: Organic Letters, Vol. 3, No. 21, 18.10.2001, p. 3277-3280.

Research output: Contribution to journalArticle

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AU - Pham, Si M.

AU - Leblanc, Roger

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AB - Equation presented A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.

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