A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK)

Yujun Zheng; Qun Huo; Peter Kele; Fotios M. Andreopoulos; Si M. Pham; Roger M. Leblanc

doi:10.1021/ol0101638

A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK)

Yujun Zheng, Qun Huo, Peter Kele, Fotios M. Andreopoulos, Si M. Pham, Roger M. Leblanc

Research output: Contribution to journal › Article › peer-review

132 Scopus citations

Abstract

Equation presented A new fluorescent chemosensor for Cu²⁺ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu²⁺, addition of Fe²⁺, Co²⁺, Ni²⁺, and Zn²⁺ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu²⁺ ions. Effects of pH were also investigated.

Original language	English (US)
Pages (from-to)	3277-3280
Number of pages	4
Journal	Organic letters
Volume	3
Issue number	21
DOIs	https://doi.org/10.1021/ol0101638
State	Published - Oct 18 2001

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0101638

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title = "A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK)",

abstract = "Equation presented A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.",

author = "Yujun Zheng and Qun Huo and Peter Kele and Andreopoulos, {Fotios M.} and Pham, {Si M.} and Leblanc, {Roger M.}",

year = "2001",

month = oct,

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doi = "10.1021/ol0101638",

language = "English (US)",

volume = "3",

pages = "3277--3280",

journal = "Organic Letters",

issn = "1523-7060",

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T1 - A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK)

AU - Zheng, Yujun

AU - Huo, Qun

AU - Kele, Peter

AU - Andreopoulos, Fotios M.

AU - Pham, Si M.

AU - Leblanc, Roger M.

PY - 2001/10/18

Y1 - 2001/10/18

N2 - Equation presented A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.

AB - Equation presented A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.

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JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 21

ER -

A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK)

Abstract

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