Abstract
Equation presented A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.
| Original language | English |
|---|---|
| Pages (from-to) | 3277-3280 |
| Number of pages | 4 |
| Journal | Organic Letters |
| Volume | 3 |
| Issue number | 21 |
| DOIs | |
| State | Published - Oct 18 2001 |
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- Molecular Medicine
Cite this
A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK). / Zheng, Yujun; Huo, Qun; Kele, Peter; Andreopoulos, Fotios M; Pham, Si M.; Leblanc, Roger.
In: Organic Letters, Vol. 3, No. 21, 18.10.2001, p. 3277-3280.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK)
AU - Zheng, Yujun
AU - Huo, Qun
AU - Kele, Peter
AU - Andreopoulos, Fotios M
AU - Pham, Si M.
AU - Leblanc, Roger
PY - 2001/10/18
Y1 - 2001/10/18
N2 - Equation presented A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.
AB - Equation presented A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.
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UR - http://www.scopus.com/inward/citedby.url?scp=0035909640&partnerID=8YFLogxK
U2 - 10.1021/ol0101638
DO - 10.1021/ol0101638
M3 - Article
VL - 3
SP - 3277
EP - 3280
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 21
ER -