A new fluorescent chemosensor for copper ions based on tripeptide glycyl-histidyl-lysine (GHK)

Yujun Zheng, Qun Huo, Peter Kele, Fotios M. Andreopoulos, Si M. Pham, Roger M. Leblanc

Research output: Contribution to journalArticle

131 Scopus citations

Abstract

Equation presented A new fluorescent chemosensor for Cu2+ ions was synthesized by modifying the tripeptide glycyl-histidyl-lysine (GHK) with 9-carbonylanthracene via the standard Fmoc solid-phase peptide synthesis method. While significant fluorescence quenching was observed from the molecule upon binding with Cu2+, addition of Fe2+, Co2+, Ni2+, and Zn2+ to the peptide solution caused a minimum fluorescence emission spectral change, indicating a high specificity of this chemosensor for Cu2+ ions. Effects of pH were also investigated.

Original languageEnglish (US)
Pages (from-to)3277-3280
Number of pages4
JournalOrganic letters
Volume3
Issue number21
DOIs
StatePublished - Oct 18 2001

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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