A new experimental model for simultaneous evaluation of aortic and pulmonary allograft performance in a composite graft

Shinji Shimokawa, Hitoshi Matsumoto, Seiji Ogata, Teruo Komokata, Seigo Nishida, Takashi Ushijima, Hideaki Saigenji, Yukinori Moriyama, Akira Taira

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1 Scopus citations

Abstract

A model was developed in pigs for simultaneous evaluation of aortic and pulmonary allograft performance in a composite graft. The composite graft consisted of vascular prosthesis and aortic and pulmonary allografts. Following antibiotic preservation, it was anastomosed to the recipient's thoracic descending aorta by an extrapleural approach without using cardiopulmonary bypass. Aortic bloodflow was completely diverted into the composite graft. All 12 recipient pigs recovered well, 4 of which were assigned for the initial study to design the suitable experimental schedule. Calcification readily occurred in the aortic allografts and aneurysmal dilatation without calcification developed in the pulmonary allografts. These morphological findings were consistent with those of previous reports. This model has several benefits. First, aortic and pulmonary allograft conduits can be implanted and evaluated simultaneously under the sane conditions by making a composite graft. Second, the magnitude of the operation is minimum, and postoperative circulatory and respiratory management is uncomplicated. Third, wound infection rarely occurs, because the skin incision is made on the back. These preliminary studies suggest that this model will allow future study concerning aortic and pulmonary allograft conduits under different conditions.

Original languageEnglish (US)
Pages (from-to)487-493
Number of pages7
JournalJournal of Investigative Surgery
Volume9
Issue number6
DOIs
StatePublished - Jan 1 1996

Keywords

  • Aortic allograft
  • Composite graft
  • Extrapleural approach
  • Pulmonary allograft

ASJC Scopus subject areas

  • Surgery

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    Shimokawa, S., Matsumoto, H., Ogata, S., Komokata, T., Nishida, S., Ushijima, T., Saigenji, H., Moriyama, Y., & Taira, A. (1996). A new experimental model for simultaneous evaluation of aortic and pulmonary allograft performance in a composite graft. Journal of Investigative Surgery, 9(6), 487-493. https://doi.org/10.3109/08941939609025866