A new estimation approach for combining epidemiological data from multiple sources

Hui Huang, Xiaomei Ma, Rasmus Waagepetersen, Theodore R. Holford, Rong Wang, Harvey Risch, Lloyd Mueller, Yongtao Guan

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We propose a novel two-step procedure to combine epidemiological data obtained from diverse sources with the aim to quantify risk factors affecting the probability that an individual develops certain disease such as cancer. In the first step, we derive all possible unbiased estimating functions based on a group of cases and a group of controls each time. In the second step, we combine these estimating functions efficiently to make full use of the information contained in data. Our approach is computationally simple and flexible. We illustrate its efficacy through simulation and apply it to investigate pancreatic cancer risks based on data obtained from the Connecticut Tumor Registry, a population-based case-control study, and the Behavioral Risk Factor Surveillance System which is a state-based system of health surveys. Supplementary materials for this article are available online.

Original languageEnglish (US)
Pages (from-to)11-23
Number of pages13
JournalJournal of the American Statistical Association
Issue number505
StatePublished - 2014


  • Estimating equation
  • Spatial epidemiology
  • Spatial point process

ASJC Scopus subject areas

  • Statistics and Probability
  • Statistics, Probability and Uncertainty


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