A new complex variant Philadelphia chromosome, t(1;9;22)ins(17;22), characterized by fluorescence in situ hybridization in an adult ALL

Yao-Shan Fan, Kamilia Rizkalla, Robert M. Barr

Research output: Contribution to journalArticle

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Abstract

A new complex variant Philadelphia chromosome was detected in a 65-year- old man with acute, pre-B, lymphoblastic leukemia (ALL). The classic cytogenetic analysis identified an apparently balanced three-way translocation t(1;9;22)(q25;q34;q11.2). Fluorescence in situ hybridization (FISH) studies confirmed the translocation and showed bcr/abl fusion on the der(22). However, these studies revealed that the distal part of the bcr gene was not translocated onto chromosome 1 at 1q25, but inserted into chromosome 17 at 17p12-13. This complex variant translocation was described as a t(1;9;22)(q25;q34;q11.2)ins(17;22)(p12-13;q11.2q11.2). Secondary changes including +8, an inversion of the derivative chromosome 9, a translocation t(14;20)(q11;q13), and an additional derivative 22 were also identified in most of the abnormal cells. The patient died from systemic fungemia and multiorgan failure 9 months after the diagnosis of ALL. The clinical significance of complex variant Philadelphia chromosomes in ALL is reviewed and discussed.

Original languageEnglish
Pages (from-to)1001-1006
Number of pages6
JournalLeukemia Research
Volume23
Issue number11
DOIs
StatePublished - Nov 1 1999
Externally publishedYes

Fingerprint

Philadelphia Chromosome
Chromosomes, Human, Pair 1
Fluorescence In Situ Hybridization
Fungemia
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 17
Cytogenetic Analysis
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genes

Keywords

  • Acute lymphoblastic leukemia
  • Bcr/abl gene fusion
  • Cytogenetics
  • Fluorescence in situ hybridization
  • Philadelphia chromosome
  • Variant Philadelphia translocation

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

A new complex variant Philadelphia chromosome, t(1;9;22)ins(17;22), characterized by fluorescence in situ hybridization in an adult ALL. / Fan, Yao-Shan; Rizkalla, Kamilia; Barr, Robert M.

In: Leukemia Research, Vol. 23, No. 11, 01.11.1999, p. 1001-1006.

Research output: Contribution to journalArticle

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