A new arteriovenous fistula model to study the development of neointimal hyperplasia

Eddie Manning, Nikolaos Skartsis, Armando M. Orta, Omaida C. Velazquez, Zhao Jun Liu, Arif Asif, Loay H. Salman, Roberto I. Vazquez-Padron

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


This study describes an alternative arteriovenous fistula (AVF) model in the rat in which the animals develop significant neointimal hyperplasia (NIH) not only at the distal anastomotic site, but also throughout the fistula body. This aortocaval fistula was established by anastomosing the distal end of the renal vein to the abdominal aorta after unilateral nephrectomy. The increased hemodynamic stress resulting from exposing the renal vein to the arterial circulation induced venous NIH as early as 7 days after surgery. This experimental AVF was characterized by the early lack of endothelium, the accumulation of proliferating vascular smooth muscle cells and the neovascularization of the fistula adventitia. In summary, we have described an informative animal model to study the pathobiology of NIH in native AVF.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalJournal of Vascular Research
Issue number2
StatePublished - Apr 2012


  • Animal model
  • Arteriovenous fistula
  • Dialysis
  • Neointima
  • Rat

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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